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Glucotoxicity and beta-cell failure in type 2 diabetes mellitus.
Kaiser N, Leibowitz G, Nesher R. Kaiser N, et al. J Pediatr Endocrinol Metab. 2003 Jan;16(1):5-22. doi: 10.1515/jpem.2003.16.1.5. J Pediatr Endocrinol Metab. 2003. PMID: 12585335 Review.
Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes.
Cohen G, Riahi Y, Sunda V, Deplano S, Chatgilialoglu C, Ferreri C, Kaiser N, Sasson S. Cohen G, et al. Among authors: kaiser n. Free Radic Biol Med. 2013 Dec;65:978-987. doi: 10.1016/j.freeradbiomed.2013.08.163. Epub 2013 Aug 20. Free Radic Biol Med. 2013. PMID: 23973638 Review.
β-Cell failure in type 2 diabetes.
Leibowitz G, Kaiser N, Cerasi E. Leibowitz G, et al. Among authors: kaiser n. J Diabetes Investig. 2011 Apr 7;2(2):82-91. doi: 10.1111/j.2040-1124.2010.00094.x. J Diabetes Investig. 2011. PMID: 24843466 Free PMC article. Review.
Beta cell response to nutrient overload involves phospholipid remodelling and lipid peroxidation.
Cohen G, Shamni O, Avrahami Y, Cohen O, Broner EC, Filippov-Levy N, Chatgilialoglu C, Ferreri C, Kaiser N, Sasson S. Cohen G, et al. Among authors: kaiser n. Diabetologia. 2015 Jun;58(6):1333-43. doi: 10.1007/s00125-015-3566-z. Epub 2015 Mar 26. Diabetologia. 2015. PMID: 25810039
Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion.
Cohen G, Riahi Y, Shamni O, Guichardant M, Chatgilialoglu C, Ferreri C, Kaiser N, Sasson S. Cohen G, et al. Among authors: kaiser n. Diabetes. 2011 Nov;60(11):2830-42. doi: 10.2337/db11-0347. Epub 2011 Sep 6. Diabetes. 2011. PMID: 21896929 Free PMC article.
These effects were blocked with GSK0660, a selective PPAR-δ antagonist, and the antioxidant N-acetylcysteine or by silencing PPAR-δ expression. ...
These effects were blocked with GSK0660, a selective PPAR-δ antagonist, and the antioxidant N-acetylcysteine or by silencing PPAR-δ e …
Calreticulin destabilizes glucose transporter-1 mRNA in vascular endothelial and smooth muscle cells under high-glucose conditions.
Totary-Jain H, Naveh-Many T, Riahi Y, Kaiser N, Eckel J, Sasson S. Totary-Jain H, et al. Among authors: kaiser n. Circ Res. 2005 Nov 11;97(10):1001-8. doi: 10.1161/01.RES.0000189260.46084.e5. Epub 2005 Oct 6. Circ Res. 2005. PMID: 16210549
A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid.
Alpert E, Gruzman A, Totary H, Kaiser N, Reich R, Sasson S. Alpert E, et al. Among authors: kaiser n. Biochem J. 2002 Mar 1;362(Pt 2):413-22. doi: 10.1042/0264-6021:3620413. Biochem J. 2002. PMID: 11853550 Free PMC article.
Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure.
Leibowitz G, Uçkaya G, Oprescu AI, Cerasi E, Gross DJ, Kaiser N. Leibowitz G, et al. Among authors: kaiser n. Endocrinology. 2002 Sep;143(9):3214-20. doi: 10.1210/en.2002-220174. Endocrinology. 2002. PMID: 12193532
Impaired glucose-stimulated insulin secretion is coupled with exocrine pancreatic lesions in the Cohen diabetic rat.
Weksler-Zangen S, Raz I, Lenzen S, Jörns A, Ehrenfeld S, Amir G, Oprescu A, Yagil Y, Yagil C, Zangen DH, Kaiser N. Weksler-Zangen S, et al. Among authors: kaiser n. Diabetes. 2008 Feb;57(2):279-87. doi: 10.2337/db07-0520. Epub 2007 Oct 31. Diabetes. 2008. PMID: 17977959
Improvement of ER stress-induced diabetes by stimulating autophagy.
Bachar-Wikstrom E, Wikstrom JD, Kaiser N, Cerasi E, Leibowitz G. Bachar-Wikstrom E, et al. Among authors: kaiser n. Autophagy. 2013 Apr;9(4):626-8. doi: 10.4161/auto.23642. Epub 2013 Feb 4. Autophagy. 2013. PMID: 23380813 Free PMC article.
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