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Methylmercury promotes prostacyclin release from cultured human brain microvascular endothelial cells via induction of cyclooxygenase-2 through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine phosphatase 1B activity.
Yoshida E, Kurita M, Eto K, Kumagai Y, Kaji T. Yoshida E, et al. Among authors: Kaji T. Toxicology. 2017 Dec 1;392:40-46. doi: 10.1016/j.tox.2017.09.013. Epub 2017 Sep 25. Toxicology. 2017. PMID: 28958600
Endothelin modulation of tissue plasminogen activator release from human vascular endothelial cells in culture.
Kaji T, Yamamoto C, Sakamoto M, Koizumi F. Kaji T, et al. Blood Coagul Fibrinolysis. 1992 Feb;3(1):5-10. doi: 10.1097/00001721-199202000-00002. Blood Coagul Fibrinolysis. 1992. PMID: 1377954
Endothelin-1 at 1 nM and above significantly decreased the release of t-PA:Ag from the endothelial cells after a 24 h incubation. ...These results strongly indicated that cyclic AMP which is known to down-regulate t-PA:Ag release was not involved in the endothelin-1 effect. ...
Endothelin-1 at 1 nM and above significantly decreased the release of t-PA:Ag from the endothelial cells after a 24 h incubation. ... …
Inhibitory effect of lead on the release of tissue plasminogen activator from human vascular endothelial cells in culture.
Kaji T, Yamamoto C, Sakamoto M, Kozuka H. Kaji T, et al. Toxicology. 1992;73(2):219-27. doi: 10.1016/0300-483x(92)90104-m. Toxicology. 1992. PMID: 1609431
Lead significantly disturbed thrombin up-regulation of t-PA:Ag release and significantly amplified endothelin-1 down-regulation of it. ...From these results, it was suggested that lead decreased the release of t-PA:Ag from cultured endothelial cells without nonspecific inhibition of protein synthesis; lead may stimulate the calcium-dependent down-regulation of endothelial cell t-PA:Ag release by calcium or by mimicking calcium....
Lead significantly disturbed thrombin up-regulation of t-PA:Ag release and significantly amplified endothelin-1 down-regulation of it …
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