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Age-related changes in the lipid compositions of rat and human tissues.
Kalén A, Appelkvist EL, Dallner G. Kalén A, et al. Lipids. 1989 Jul;24(7):579-84. doi: 10.1007/BF02535072. Lipids. 1989. PMID: 2779364
In contrast, the levels of the phosphorylated derivative of dolichol increased to a more limited extent, i.e., 2 to 6-fold in human tissues and even less in the rat. These results demonstrate that the levels of a number of lipids in human and rat organs are modified …
In contrast, the levels of the phosphorylated derivative of dolichol increased to a more limited extent, i.e., 2 to 6-fold in human t …
Ubiquinone biosynthesis by the microsomal fraction from rat liver.
Kalén A, Norling B, Appelkvist EL, Dallner G. Kalén A, et al. Biochim Biophys Acta. 1987 Oct 8;926(1):70-8. doi: 10.1016/0304-4165(87)90183-8. Biochim Biophys Acta. 1987. PMID: 3651503
Effects of inhibitors of hydroxymethylglutaryl coenzyme A reductase on coenzyme Q and dolichol biosynthesis.
Appelkvist EL, Edlund C, Löw P, Schedin S, Kalén A, Dallner G. Appelkvist EL, et al. Among authors: kalen a. Clin Investig. 1993;71(8 Suppl):S97-102. doi: 10.1007/BF00226848. Clin Investig. 1993. PMID: 8241713
Inhibitors of hydroxymethylglutaryl coenzyme A reductase are used clinically to decrease blood levels of low-density lipoprotein cholesterol in hypercholesterolemic patients. ...It appears that these HMG-coenzyme A reductase inhibitors do not selectively lower chole …
Inhibitors of hydroxymethylglutaryl coenzyme A reductase are used clinically to decrease blood levels of low-density lipoprotein chol …
In vitro and in vivo synthesis of dolichol and other main mevalonate products in various organs of the rat.
Elmberger PG, Kalèn A, Appelkvist EL, Dallner G. Elmberger PG, et al. Among authors: kalen a. Eur J Biochem. 1987 Oct 1;168(1):1-11. doi: 10.1111/j.1432-1033.1987.tb13379.x. Eur J Biochem. 1987. PMID: 3665910
Equilibration of this pool with exogenous mevalonate is a rapid and passive process. The size of the mevalonate pool does not determine the rates of cholesterol and dolichol biosynthesis, indicating the presence of regulatory steps in the terminal portion of these biosynth …
Equilibration of this pool with exogenous mevalonate is a rapid and passive process. The size of the mevalonate pool does not determi …
Discharge of newly-synthesized dolichol and ubiquinone with lipoproteins to rat liver perfusate and to the bile.
Elmberger PG, Kalén A, Brunk UT, Dallner G. Elmberger PG, et al. Among authors: kalen a. Lipids. 1989 Nov;24(11):919-30. doi: 10.1007/BF02544535. Lipids. 1989. PMID: 2615561
Infusion of taurocholate and glucose proved necessary to maintain stable metabolic activity and bile secretion during a 6-hr period. ...
Infusion of taurocholate and glucose proved necessary to maintain stable metabolic activity and bile secretion during a 6-hr period. …
Biosynthesis of dolichol by rat liver peroxisomes.
Appelkvist EL, Kalén A. Appelkvist EL, et al. Among authors: kalen a. Eur J Biochem. 1989 Nov 20;185(3):503-9. doi: 10.1111/j.1432-1033.1989.tb15142.x. Eur J Biochem. 1989. PMID: 2591375
Uptake and metabolism of dolichol and cholesterol in perfused rat liver.
Kalén A, Söderberg M, Elmberger PG, Dallner G. Kalén A, et al. Lipids. 1990 Feb;25(2):93-9. doi: 10.1007/BF02562211. Lipids. 1990. PMID: 2329927
Accumulation of these lipids occurred in lysosomes followed by a transport to the endoplasmic reticulum (ER). Both labeled dolichol and cholesterol appeared in the bile. ...It appears that, in contrast to the receptor-mediated uptake of lipoproteins from the perfusate, the …
Accumulation of these lipids occurred in lysosomes followed by a transport to the endoplasmic reticulum (ER). Both labeled dolichol a …
Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver.
Kalén A, Appelkvist EL, Chojnacki T, Dallner G. Kalén A, et al. J Biol Chem. 1990 Jan 15;265(2):1158-64. J Biol Chem. 1990. PMID: 2295606
In the total microsomal fraction, the enzyme had a pH optimum of 7.5 and was completely inhibited by Triton X-100 and deoxycholate, but not by taurodeoxycholate and beta-octyl glucoside. ...When the product of the transferase reaction was used as a substrate in vitr …
In the total microsomal fraction, the enzyme had a pH optimum of 7.5 and was completely inhibited by Triton X-100 and deoxycholate, b …
Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia.
Elmberger PG, Kalén A, Lund E, Reihnér E, Eriksson M, Berglund L, Angelin B, Dallner G. Elmberger PG, et al. Among authors: kalen a. J Lipid Res. 1991 Jun;32(6):935-40. J Lipid Res. 1991. PMID: 1940625
Patients with heterozygous familial hypercholesterolemia (n = 12) were treated either with pravastatin, a specific inhibitor of HMG-CoA reductase, or cholestyramine, followed by a period of combined treatment with both drugs. ...In this case, the amount of dolichol …
Patients with heterozygous familial hypercholesterolemia (n = 12) were treated either with pravastatin, a specific inhibitor of HMG-C …
The effects of inducers of the endoplasmic reticulum, peroxisomes and mitochondria on the amounts and synthesis of ubiquinone in rat liver subcellular membranes.
Kalén A, Appelkvist EL, Dallner G. Kalén A, et al. Chem Biol Interact. 1990;73(2-3):221-34. doi: 10.1016/0009-2797(90)90005-8. Chem Biol Interact. 1990. PMID: 2311131
Treatment with clofibrate and 2-diethylhexylphthalate (DEHP) increased microsomal and mitochondrial ubiquinone contents, but a decrease was observed in lysosomes. ...The results demonstrate that the ubiquinone contents of the various membranes of hepatocytes change in a
Treatment with clofibrate and 2-diethylhexylphthalate (DEHP) increased microsomal and mitochondrial ubiquinone contents, but a decrea …
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