Kalgutkar AS - Search Results

1

Drug discovery for a new generation of covalent drugs.

Kalgutkar AS, Dalvie DK. Kalgutkar AS, et al. Expert Opin Drug Discov. 2012 Jul;7(7):561-81. doi: 10.1517/17460441.2012.688744. Epub 2012 May 19. Expert Opin Drug Discov. 2012. PMID: 22607458 Review.

2

Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors.

Kalgutkar AS, Dalvie DK, Castagnoli N Jr, Taylor TJ. Kalgutkar AS, et al. Chem Res Toxicol. 2001 Sep;14(9):1139-62. doi: 10.1021/tx010073b. Chem Res Toxicol. 2001. PMID: 11559028 Review. No abstract available.

3

Biotransformation reactions of five-membered aromatic heterocyclic rings.

Dalvie DK, Kalgutkar AS, Khojasteh-Bakht SC, Obach RS, O'Donnell JP. Dalvie DK, et al. Among authors: kalgutkar as. Chem Res Toxicol. 2002 Mar;15(3):269-99. doi: 10.1021/tx015574b. Chem Res Toxicol. 2002. PMID: 11896674 Review. No abstract available.

4

On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics.

Kalgutkar AS, Dalvie DK, O'Donnell JP, Taylor TJ, Sahakian DC. Kalgutkar AS, et al. Curr Drug Metab. 2002 Aug;3(4):379-424. doi: 10.2174/1389200023337360. Curr Drug Metab. 2002. PMID: 12093357 Review.

5

In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes.

Kalgutkar AS, Nguyen HT, Vaz AD, Doan A, Dalvie DK, McLeod DG, Murray JC. Kalgutkar AS, et al. Drug Metab Dispos. 2003 Oct;31(10):1240-50. doi: 10.1124/dmd.31.10.1240. Drug Metab Dispos. 2003. PMID: 12975333

6

Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.

O'Donnell JP, Dalvie DK, Kalgutkar AS, Obach RS. O'Donnell JP, et al. Among authors: kalgutkar as. Drug Metab Dispos. 2003 Nov;31(11):1369-77. doi: 10.1124/dmd.31.11.1369. Drug Metab Dispos. 2003. PMID: 14570769

7

A comprehensive listing of bioactivation pathways of organic functional groups.

Kalgutkar AS, Gardner I, Obach RS, Shaffer CL, Callegari E, Henne KR, Mutlib AE, Dalvie DK, Lee JS, Nakai Y, O'Donnell JP, Boer J, Harriman SP. Kalgutkar AS, et al. Curr Drug Metab. 2005 Jun;6(3):161-225. doi: 10.2174/1389200054021799. Curr Drug Metab. 2005. PMID: 15975040 Review.

8

Minimising the potential for metabolic activation in drug discovery.

Kalgutkar AS, Soglia JR. Kalgutkar AS, et al. Expert Opin Drug Metab Toxicol. 2005 Jun;1(1):91-142. doi: 10.1517/17425255.1.1.91. Expert Opin Drug Metab Toxicol. 2005. PMID: 16922655 Review.

9

Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.

Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV Jr, Soliman VF, Schildknegt K. Kalgutkar AS, et al. Drug Metab Dispos. 2007 Jun;35(6):848-58. doi: 10.1124/dmd.106.013649. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344339

10

Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions.

Kalgutkar AS, Obach RS, Maurer TS. Kalgutkar AS, et al. Curr Drug Metab. 2007 Jun;8(5):407-47. doi: 10.2174/138920007780866807. Curr Drug Metab. 2007. PMID: 17584015 Review.

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