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The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ.
Philipson O, Lord A, Lalowski M, Soliymani R, Baumann M, Thyberg J, Bogdanovic N, Olofsson T, Tjernberg LO, Ingelsson M, Lannfelt L, Kalimo H, Nilsson LN. Philipson O, et al. Among authors: kalimo h. Neurobiol Aging. 2012 May;33(5):1010.e1-13. doi: 10.1016/j.neurobiolaging.2011.10.022. Epub 2011 Nov 26. Neurobiol Aging. 2012. PMID: 22118948
Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation.
Fagerqvist T, Lindström V, Nordström E, Lord A, Tucker SM, Su X, Sahlin C, Kasrayan A, Andersson J, Welander H, Näsström T, Holmquist M, Schell H, Kahle PJ, Kalimo H, Möller C, Gellerfors P, Lannfelt L, Bergström J, Ingelsson M. Fagerqvist T, et al. Among authors: kalimo h. J Neurochem. 2013 Jul;126(1):131-44. doi: 10.1111/jnc.12175. Epub 2013 Feb 27. J Neurochem. 2013. PMID: 23363402
The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ.
Kalimo H, Lalowski M, Bogdanovic N, Philipson O, Bird TD, Nochlin D, Schellenberg GD, Brundin R, Olofsson T, Soliymani R, Baumann M, Wirths O, Bayer TA, Nilsson LN, Basun H, Lannfelt L, Ingelsson M. Kalimo H, et al. Acta Neuropathol Commun. 2013 Sep 10;1:60. doi: 10.1186/2051-5960-1-60. Acta Neuropathol Commun. 2013. PMID: 24252272 Free PMC article.
The tau S305S mutation causes frontotemporal dementia with parkinsonism.
Skoglund L, Viitanen M, Kalimo H, Lannfelt L, Jönhagen ME, Ingelsson M, Glaser A, Herva R. Skoglund L, et al. Among authors: kalimo h. Eur J Neurol. 2008 Feb;15(2):156-61. doi: 10.1111/j.1468-1331.2007.02017.x. Epub 2007 Dec 18. Eur J Neurol. 2008. PMID: 18093153
334 results