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Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs.
Cole PD, Smith AK, Kamen BA. Cole PD, et al. Among authors: kamen ba. Cancer Chemother Pharmacol. 2002 Aug;50(2):111-6. doi: 10.1007/s00280-002-0478-7. Epub 2002 Jun 14. Cancer Chemother Pharmacol. 2002. PMID: 12172974
Methotrexate (MTX) concentration in tumors following low-dose MTX.
Winick NJ, Kamen BA, Streckfuss A, Craig J, McGuirt F, Capizzi RL, Sklar F, Coln D. Winick NJ, et al. Among authors: kamen ba. Cancer Chemother Pharmacol. 1987;20(1):78-80. doi: 10.1007/BF00252965. Cancer Chemother Pharmacol. 1987. PMID: 2441884
A phase II trial of continuous-infusion 6-mercaptopurine for childhood solid tumors.
Adamson PC, Zimm S, Ragab AH, Steinberg SM, Balis F, Kamen BA, Vietti TJ, Gillespie A, Poplack DG. Adamson PC, et al. Among authors: kamen ba. Cancer Chemother Pharmacol. 1990;26(5):343-4. doi: 10.1007/BF02897290. Cancer Chemother Pharmacol. 1990. PMID: 2208575
Low-dose methotrexate therapy for hepatoblastoma.
Weitman SD, Kato GJ, Barbosa JL, Kamen BA. Weitman SD, et al. Among authors: kamen ba. Cancer Chemother Pharmacol. 1991;28(3):233-4. doi: 10.1007/BF00685519. Cancer Chemother Pharmacol. 1991. PMID: 1649707 No abstract available.
A phase II trial of continuous-infusion 6-mercaptopurine for childhood leukemia.
Adamson PC, Zimm S, Ragab AH, Balis F, Steinberg SM, Kamen BA, Vietti TJ, Gillespie A, Poplack DG. Adamson PC, et al. Among authors: kamen ba. Cancer Chemother Pharmacol. 1992;30(2):155-7. doi: 10.1007/BF00686410. Cancer Chemother Pharmacol. 1992. PMID: 1600597 Clinical Trial.
A mechanism of resistance to methotrexate. NADPH but not NADH stimulation of methotrexate binding to dihydrofolate reductase.
Kamen BA, Whyte-Bauer W, Bertino JR. Kamen BA, et al. Biochem Pharmacol. 1983 Jun 15;32(12):1837-41. doi: 10.1016/0006-2952(83)90047-3. Biochem Pharmacol. 1983. PMID: 6882460
Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
Ohnoshi T, Ohnuma T, Takahashi I, Scanlon K, Kamen BA, Holland JF. Ohnoshi T, et al. Among authors: kamen ba. Cancer Res. 1982 May;42(5):1655-60. Cancer Res. 1982. PMID: 6978176
Effects of overexpression of gamma-Glutamyl hydrolase on methotrexate metabolism and resistance.
Cole PD, Kamen BA, Gorlick R, Banerjee D, Smith AK, Magill E, Bertino JR. Cole PD, et al. Among authors: kamen ba. Cancer Res. 2001 Jun 1;61(11):4599-604. Cancer Res. 2001. PMID: 11389096
Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro.
Ohnuma T, Lo RJ, Scanlon KJ, Kamen BA, Ohnoshi T, Wolman SR, Holland JF. Ohnuma T, et al. Among authors: kamen ba. Cancer Res. 1985 Apr;45(4):1815-22. Cancer Res. 1985. PMID: 3856477
Methotrexate metabolism.
Krakower GR, Kamen BA. Krakower GR, et al. Among authors: kamen ba. Cancer Chemother Pharmacol. 1983;10(3):230-1. doi: 10.1007/BF00255773. Cancer Chemother Pharmacol. 1983. PMID: 6861270 No abstract available.
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