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Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study.
Nakamura E, Aoki M, Watanabe F, Kamimura A. Nakamura E, et al. Nutr J. 2014 Aug 27;13:85. doi: 10.1186/1475-2891-13-85. Nutr J. 2014. PMID: 25163392 Free PMC article.
BACKGROUND: Menaquinone-4 is a type of vitamin K that has a physiological function in maintaining bone quality via γ-carboxylation of osteocalcin. ...FINDINGS: Fifteen healthy males aged 25.0 years (median) participated in a non-placebo-controlled dose-examin …
BACKGROUND: Menaquinone-4 is a type of vitamin K that has a physiological function in maintaining bone quality via γ-carboxyla …
The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males.
Suzuki T, Morita M, Hayashi T, Kamimura A. Suzuki T, et al. Biosci Biotechnol Biochem. 2017 Feb;81(2):372-375. doi: 10.1080/09168451.2016.1230007. Epub 2016 Sep 26. Biosci Biotechnol Biochem. 2017. PMID: 27667025 Clinical Trial.
Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.
Suzuki T, Morita M, Kobayashi Y, Kamimura A. Suzuki T, et al. J Int Soc Sports Nutr. 2016 Feb 19;13:6. doi: 10.1186/s12970-016-0117-z. eCollection 2016. J Int Soc Sports Nutr. 2016. PMID: 26900386 Free PMC article. Clinical Trial.
This is because NO is a potential modulator of blood flow, muscle energy metabolism, and mitochondrial respiration during exercise. L-Citrulline is an amino acid present in the body and is a potent endogenous precursor of L-arginine, which is a substrate for …
This is because NO is a potential modulator of blood flow, muscle energy metabolism, and mitochondrial respiration during exercise. L …
A single-blind, parallel trial of L-hydroxyproline in healthy adult subjects.
Akiduki S, Ito H, Morishita K, Kamimura A. Akiduki S, et al. Urolithiasis. 2015 Jun;43(3):289-92. doi: 10.1007/s00240-015-0765-5. Epub 2015 Apr 1. Urolithiasis. 2015. PMID: 25827754 Free PMC article. No abstract available.
Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women.
Watanabe F, Hashizume E, Chan GP, Kamimura A. Watanabe F, et al. Clin Cosmet Investig Dermatol. 2014 Oct 17;7:267-74. doi: 10.2147/CCID.S68424. eCollection 2014. Clin Cosmet Investig Dermatol. 2014. PMID: 25378941 Free PMC article.
PURPOSE: Glutathione is a tripeptide consisting of cysteine, glycine, and glutamate and functions as a major antioxidant. It is synthesized endogenously in humans. ...The study design was a randomized, double-blind, matched-pair, placebo-controlled clinical t …
PURPOSE: Glutathione is a tripeptide consisting of cysteine, glycine, and glutamate and functions as a major antioxidant. It i …
Increasing effect of an oral intake of L-hydroxyproline on the soluble collagen content of skin and collagen fragments in rat serum.
Aoki M, Suto K, Komatsu M, Kamimura A, Morishita K, Yamasaki M, Takao T. Aoki M, et al. Biosci Biotechnol Biochem. 2012;76(6):1242-4. doi: 10.1271/bbb.120058. Biosci Biotechnol Biochem. 2012. PMID: 22790956
Procyanidin B-3, isolated from barley and identified as a hair-growth stimulant, has the potential to counteract inhibitory regulation by TGF-beta1.
Kamimura A, Takahashi T. Kamimura A, et al. Exp Dermatol. 2002 Dec;11(6):532-41. doi: 10.1034/j.1600-0625.2002.110606.x. Exp Dermatol. 2002. PMID: 12473061
For the purpose of examining the hair-growing mechanisms of procyanidin B-3, we examined its relationship to the TGF-beta signal pathway, which is known to be a regulator of catagen induction. ...
For the purpose of examining the hair-growing mechanisms of procyanidin B-3, we examined its relationship to the TGF-beta signal pathway, wh …
Procyanidin oligomers counteract TGF-beta1- and TGF-beta2-induced apoptosis in hair epithelial cells: an insight into their mechanisms.
Kamimura A, Takahashi T, Morohashi M, Takano Y. Kamimura A, et al. Skin Pharmacol Physiol. 2006;19(5):259-65. doi: 10.1159/000093981. Epub 2006 Jun 16. Skin Pharmacol Physiol. 2006. PMID: 16778458
For the purpose of examining the hair-growing mechanisms of procyanidin oligomers, we examined their relationship to the TGF-beta signal pathway, known to be a regulator of catagen induction, and the mitogen-activated protein kinase cascade linked to cell proliferation. .. …
For the purpose of examining the hair-growing mechanisms of procyanidin oligomers, we examined their relationship to the TGF-beta signal pat …
l-Citrulline ameliorates cerebral blood flow during cortical spreading depression in rats: Involvement of nitric oxide- and prostanoids-mediated pathway.
Kurauchi Y, Mokudai K, Mori A, Sakamoto K, Nakahara T, Morita M, Kamimura A, Ishii K. Kurauchi Y, et al. J Pharmacol Sci. 2017 Mar;133(3):146-155. doi: 10.1016/j.jphs.2017.02.004. Epub 2017 Feb 17. J Pharmacol Sci. 2017. PMID: 28325558
l-Citrulline is a potent precursor of l-arginine, and exerts beneficial effect on cardiovascular system via nitric oxide (NO) production. ...In addition, propagation velocity of CSD was attenuated by intravenous injection of NOR3, a NO donor, which was diminished by …
l-Citrulline is a potent precursor of l-arginine, and exerts beneficial effect on cardiovascular system via nitric oxide (NO) product …
Topical effects of N-acetyl-L-hydroxyproline on ceramide synthesis and alleviation of pruritus.
Hashizume E, Nakano T, Kamimura A, Morishita K. Hashizume E, et al. Clin Cosmet Investig Dermatol. 2013;6:43-9. doi: 10.2147/CCID.S39370. Epub 2013 Feb 12. Clin Cosmet Investig Dermatol. 2013. PMID: 23430142 Free PMC article.
MATERIALS AND METHODS: AHYP was applied to a three-dimensional cultured skin model. Ceramides were quantified by high-performance thin-layer chromatography. ...Dermatological observations were made by a dermatologist, and subjects evaluated their own pruritus intens …
MATERIALS AND METHODS: AHYP was applied to a three-dimensional cultured skin model. Ceramides were quantified by high-performance thi …
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