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Ampicillin and cephalexin in renal insufficiency.
Hori R, Okumura K, Kamiya A, Nihira H, Nakano H. Hori R, et al. Among authors: kamiya a. Clin Pharmacol Ther. 1983 Dec;34(6):792-8. doi: 10.1038/clpt.1983.251. Clin Pharmacol Ther. 1983. PMID: 6641095
We analyzed the relationship between functional damage and transport processes in the kidney in patients with glomerulonephritis and renal failure by a new analytic method. ...Our data point to a need for a prolongation of the dosage interval of cephalexin to …
We analyzed the relationship between functional damage and transport processes in the kidney in patients with glomerulonephritis and renal f …
A new dosing regimen in renal insufficiency: application to cephalexin.
Hori R, Okumura K, Nihira H, Nakano H, Akagi K, Kamiya A. Hori R, et al. Among authors: kamiya a. Clin Pharmacol Ther. 1985 Sep;38(3):290-5. doi: 10.1038/clpt.1985.173. Clin Pharmacol Ther. 1985. PMID: 4028624
In the new method, CLCR and the 15-minute phenolsulfonphthalein (PSP15') test were used and applied to patients with renal insufficiency with cephalexin (CEX) as a model drug for renal tubular secretion. ...A nomogram for the CEX dosing interval is proposed for appl …
In the new method, CLCR and the 15-minute phenolsulfonphthalein (PSP15') test were used and applied to patients with renal insufficiency wit …
Quantitative investigation of renal handling of drugs in dogs with renal insufficiency.
Kamiya A, Okumura K, Hori R. Kamiya A, et al. J Pharm Sci. 1984 Jul;73(7):892-6. doi: 10.1002/jps.2600730708. J Pharm Sci. 1984. PMID: 6236294
A quantitative analytical method for studying renal handling of drugs in dogs with mild renal impairment is described. Renal damage was induced experimentally by pretreatment with mercuric chloride or neomycin. Analytical results of renal handling in those animals indicate
A quantitative analytical method for studying renal handling of drugs in dogs with mild renal impairment is described. Renal damage w
Quantitative investigation on renal handling of drugs in rabbits, dogs, and humans.
Kamiya A, Okumura K, Hori R. Kamiya A, et al. J Pharm Sci. 1983 Apr;72(4):440-3. doi: 10.1002/jps.2600720429. J Pharm Sci. 1983. PMID: 6864487
A renal clearance method based on a computer analysis after administration of a single dose of drug was developed for measuring the renal handling of several drugs in rabbits, dogs, and humans. ...
A renal clearance method based on a computer analysis after administration of a single dose of drug was developed for m
Pharmacokinetics of nitroglycerin after parenteral and oral dosing in the rat.
Fung HL, Ogata H, Kamiya A, Maier GA. Fung HL, et al. Among authors: kamiya a. J Pharm Sci. 1984 Jul;73(7):873-9. doi: 10.1002/jps.2600730704. J Pharm Sci. 1984. PMID: 6432996
A terminal half-life of approximately 15 min was observed after high intravenous bolus doses of nitroglycerin. This slow disappearance phase was likely rate limited by redistribution of drug back into the plasma. ...Coadministration of mannitol hexanitrate, a potent
A terminal half-life of approximately 15 min was observed after high intravenous bolus doses of nitroglycerin. This slow disappearanc
Effects of nephrotoxic compounds on active uptake of drugs in isolated renal tubules in rabbits.
Okumura K, Yamakita H, Kamiya A, Hori R. Okumura K, et al. Among authors: kamiya a. Biochem Pharmacol. 1984 Jul 1;33(13):2055-9. doi: 10.1016/0006-2952(84)90573-2. Biochem Pharmacol. 1984. PMID: 6331456
The inhibitory action of the three antibiotics corresponds with in vivo potency, suggesting that this renal tubule preparation may provide a simple method for predicting the nephrotoxicity of drugs....
The inhibitory action of the three antibiotics corresponds with in vivo potency, suggesting that this renal tubule preparation may provide …
Tissue distribution and metabolism of drugs. I. Quantitative investigation on renal handling of phenolsulfonphthalein and sulfonamides in rabbits.
Hori R, Sunayashiki K, Kamiya A. Hori R, et al. Among authors: kamiya a. Chem Pharm Bull (Tokyo). 1978 Mar;26(3):740-5. doi: 10.1248/cpb.26.740. Chem Pharm Bull (Tokyo). 1978. PMID: 647849 No abstract available.
Pharmacokinetic analysis of renal handling of sulfamethizole.
Hori R, Sunayashiki K, Kamiya A. Hori R, et al. Among authors: kamiya a. J Pharm Sci. 1976 Mar;65(3):463-5. doi: 10.1002/jps.2600650345. J Pharm Sci. 1976. PMID: 1263108 No abstract available.
Rectal absorption of nitroglycerin in the rat: avoidance of first-pass metabolism as a function of rectal length exposure.
Kamiya A, Ogata H, Fung HL. Kamiya A, et al. J Pharm Sci. 1982 Jun;71(6):621-4. doi: 10.1002/jps.2600710606. J Pharm Sci. 1982. PMID: 6808113
In applying this concept to nitroglycerin in rats, it was found that unrestricted rectal instillation of nitroglycerin (at 3.5-mg/kg dose) gave a mean +/-SD bioavailability of 26.7 +/- 7.0% (n=6) compared to 1.8 +/- 0.9% (n=5) from oral dosing. ...
In applying this concept to nitroglycerin in rats, it was found that unrestricted rectal instillation of nitroglycerin (at 3.5-mg/kg dose) g …
Blood vessel uptake and metabolism of organic nitrates in the rat.
Fung HL, Sutton SC, Kamiya A. Fung HL, et al. Among authors: kamiya a. J Pharmacol Exp Ther. 1984 Feb;228(2):334-41. J Pharmacol Exp Ther. 1984. PMID: 6420543
Blood vessel segments nearest the input site had the greatest amounts of nitrate, whereas segments further away from the input site had progressively less nitrate, with the exception of aorta, which appeared to take up NTG less extensively, on a per weight of vessel basis, …
Blood vessel segments nearest the input site had the greatest amounts of nitrate, whereas segments further away from the input site had prog …
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