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Blockade of CD7 expression in T cells for effective chimeric antigen receptor targeting of T-cell malignancies.
Png YT, et al. Blood Adv 2017. Among authors: Kamiya T. PMID 29296885 Free PMC article.
Effective immunotherapies for T-cell malignancies are lacking. We devised a novel approach based on chimeric antigen receptor (CAR)-redirected T lymphocytes. We selected CD7 as a target because of its consistent expression in T-cell acute lymphoblastic leukemia (T-ALL), including the most aggressive subtype, early T-cell precursor (ETP)-ALL. ...
Effective immunotherapies for T-cell malignancies are lacking. We devised a novel approach based on chimeric antigen receptor (CAR)-r …
A novel method to generate T-cell receptor-deficient chimeric antigen receptor T cells.
Kamiya T, et al. Blood Adv 2018. PMID 29507075 Free PMC article.
Using donor-derived CAR-T cells is attractive, but expression of endogenous T-cell receptors (TCRs) carries the risk for graft-versus-host-disease (GVHD). ...In 25 experiments, median TCRαβ expression in T lymphocytes was reduced from 95.7% to 25.0%; CD3/TCRαβ cell depletion yielded virtually pure TCRαβ-negative T cells. ...
Using donor-derived CAR-T cells is attractive, but expression of endogenous T-cell receptors (TCRs) carries the risk for graft …
Expanded and armed natural killer cells for cancer treatment
Shimasaki N, et al. Cytotherapy 2016 - Review. Among authors: Kamiya T. PMID 27497701
Allogeneic NK cells are not direct effectors of graft-versus-host disease but this may occur if donor NK cells are infused after allogeneic hematopoietic stem cell transplant, which may activate T cell alloreactivity. ...
Allogeneic NK cells are not direct effectors of graft-versus-host disease but this may occur if donor NK cells are infused after allogeneic …
T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing.
Kudo K, et al. Cancer Res 2014. Among authors: Kamiya T. PMID 24197131
To expand applications for T-cell-based immunotherapy in cancer, we designed a receptor that binds the Fc portion of human immunoglobulins and delivers activation signals. ...Furthermore, coadministration of CD16V-BB-ζ T cells with immunotherapeutic antibodies exerted considerable antitumor activity in vivo. ...
To expand applications for T-cell-based immunotherapy in cancer, we designed a receptor that binds the Fc portion of human immunoglob …
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