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Activated hepatic stellate cells mediate the differentiation of macrophages.
Chang J, Hisamatsu T, Shimamura K, Yoneno K, Adachi M, Naruse H, Igarashi T, Higuchi H, Matsuoka K, Kitazume MT, Ando S, Kamada N, Kanai T, Hibi T. Chang J, et al. Among authors: Kanai T. Hepatol Res. 2013 Jun;43(6):658-69. doi: 10.1111/j.1872-034X.2012.01111.x. Epub 2012 Oct 29. Hepatol Res. 2013. PMID: 23107150
Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa.
Nakazawa A, Watanabe M, Kanai T, Yajima T, Yamazaki M, Ogata H, Ishii H, Azuma M, Hibi T. Nakazawa A, et al. Among authors: Kanai T. Gastroenterology. 1999 Sep;117(3):536-45. doi: 10.1016/s0016-5085(99)70446-4. Gastroenterology. 1999. PMID: 10464129
BACKGROUND & AIMS: Costimulatory signals are essential for T-cell activation. The aim of this study was to demonstrate expression of costimulatory molecules CD86 and CD80 in human colonic epithelial cells and assess their functional roles in the activation of T
BACKGROUND & AIMS: Costimulatory signals are essential for T-cell activation. The aim of this study was to demonstrate expression …
Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease.
Kanai T, Watanabe M, Okazawa A, Nakamaru K, Okamoto M, Naganuma M, Ishii H, Ikeda M, Kurimoto M, Hibi T. Kanai T, et al. Gastroenterology. 2000 Dec;119(6):1514-23. doi: 10.1053/gast.2000.20260. Gastroenterology. 2000. PMID: 11113073
BACKGROUND & AIMS: Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4(+) T cells and macrophages in inflamed intestinal mucosa. Interleukin (IL)-18 is a recently described cytokine that mainly exists in activated macrophages and sh …
BACKGROUND & AIMS: Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4(+) T cells and macrop …
Interleukin-18 and Crohn's disease.
Kanai T, Watanabe M, Okazawa A, Sato T, Hibi T. Kanai T, et al. Digestion. 2001;63 Suppl 1:37-42. doi: 10.1159/000051909. Digestion. 2001. PMID: 11173908
Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 i …
Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intesti …
Human leukocyte antigen-G-expressing cells differently modulate the release of cytokines from mononuclear cells present in the decidua versus peripheral blood.
Kanai T, Fujii T, Unno N, Yamashita T, Hyodo H, Miki A, Hamai Y, Kozuma S, Taketani Y. Kanai T, et al. Am J Reprod Immunol. 2001 Feb;45(2):94-9. doi: 10.1111/j.8755-8920.2001.450205.x. Am J Reprod Immunol. 2001. PMID: 11216880
PROBLEM: To better understand the role of human leukocyte antigen (HLA)-G in regulating the T helper (Th)1/Th2 cytokine balance, one of key conditions in determining the fate of pregnancy, we asked whether the presence of HLA-G protein altered the release of cytokines from …
PROBLEM: To better understand the role of human leukocyte antigen (HLA)-G in regulating the T helper (Th)1/Th2 cytokine balance, one …
Characterization of structures with T-lymphocyte aggregates in ileal villi of Crohn's disease.
Naganuma M, Watanabe M, Kanai T, Iwao Y, Mukai M, Ishii H, Hibi T. Naganuma M, et al. Among authors: Kanai T. Am J Gastroenterol. 2002 Jul;97(7):1741-7. doi: 10.1111/j.1572-0241.2002.05834.x. Am J Gastroenterol. 2002. PMID: 12135029
Here, we demonstrated unique structures with T-lymphocyte aggregates (TLAs) that were specifically found in ileal villi of CD. ...These structures were not detected in any normal or UC intestine. 2) These structures were composed mainly of T cells, and CD4+ CD45RO+ …
Here, we demonstrated unique structures with T-lymphocyte aggregates (TLAs) that were specifically found in ileal villi of CD. ...The …
Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement.
Okazawa A, Kanai T, Watanabe M, Yamazaki M, Inoue N, Ikeda M, Kurimoto M, Ishii H, Hibi T. Okazawa A, et al. Among authors: Kanai T. Am J Gastroenterol. 2002 Dec;97(12):3108-17. doi: 10.1111/j.1572-0241.2002.07107.x. Am J Gastroenterol. 2002. PMID: 12492197
OBJECTIVE: The development of T helper type 1 (Th1) CD4+ T cells in the intestinal mucosa is driven by interleukin (IL)-12 produced from activated macrophages and IL-18 produced from activated macrophages and epithelial cells. ...CONCLUSIONS: These findings suggest …
OBJECTIVE: The development of T helper type 1 (Th1) CD4+ T cells in the intestinal mucosa is driven by interleukin (IL)-12 pro …
Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis.
Totsuka T, Kanai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M. Totsuka T, et al. Among authors: Kanai T. Gastroenterology. 2003 Feb;124(2):410-21. doi: 10.1053/gast.2003.50050. Gastroenterology. 2003. PMID: 12557147
Th2 cytokine production and apoptosis in infiltrating T cells was examined after administration of anti-ICOS mAb. RESULTS: ICOS was strongly induced on CD4(+) T cells, and B7RP-1 was expressed by macrophages in the inflamed mucosa of colitic mice. ...Transfer of CD4 …
Th2 cytokine production and apoptosis in infiltrating T cells was examined after administration of anti-ICOS mAb. RESULTS: ICOS was s …
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