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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.
Kandel ES, Hay N. Kandel ES, et al. Exp Cell Res. 1999 Nov 25;253(1):210-29. doi: 10.1006/excr.1999.4690. Exp Cell Res. 1999. PMID: 10579924 Review.
Transposon-based mutagenesis identifies short RIP1 as an activator of NFkappaB.
Dasgupta M, Agarwal MK, Varley P, Lu T, Stark GR, Kandel ES. Dasgupta M, et al. Among authors: kandel es. Cell Cycle. 2008 Jul 15;7(14):2249-56. doi: 10.4161/cc.7.14.6310. Epub 2008 May 17. Cell Cycle. 2008. PMID: 18635966
Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly.
Somanath PR, Kandel ES, Hay N, Byzova TV. Somanath PR, et al. Among authors: kandel es. J Biol Chem. 2007 Aug 3;282(31):22964-76. doi: 10.1074/jbc.M700241200. Epub 2007 Jun 11. J Biol Chem. 2007. PMID: 17562714 Free PMC article.
c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.
Brunelle JK, Santore MT, Budinger GR, Tang Y, Barrett TA, Zong WX, Kandel E, Keith B, Simon MC, Thompson CB, Hay N, Chandel NS. Brunelle JK, et al. Among authors: kandel e. J Biol Chem. 2004 Feb 6;279(6):4305-12. doi: 10.1074/jbc.M312241200. Epub 2003 Nov 19. J Biol Chem. 2004. PMID: 14627695
The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt.
Somanath PR, Vijai J, Kichina JV, Byzova T, Kandel ES. Somanath PR, et al. Among authors: kandel es. Oncogene. 2009 Jun 25;28(25):2365-9. doi: 10.1038/onc.2009.114. Epub 2009 May 4. Oncogene. 2009. PMID: 19421139 Free PMC article.
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase.
Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. Gottlob K, et al. Among authors: kandel e. Genes Dev. 2001 Jun 1;15(11):1406-18. doi: 10.1101/gad.889901. Genes Dev. 2001. PMID: 11390360 Free PMC article.
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.
Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CS, Gartel A, Hay N. Kandel ES, et al. Mol Cell Biol. 2002 Nov;22(22):7831-41. doi: 10.1128/mcb.22.22.7831-7841.2002. Mol Cell Biol. 2002. PMID: 12391152 Free PMC article.
In addition, we found that PTEN null embryonic stem (ES) cells transit faster from the G(2)/M to the G(1) phase of the cell cycle when compared to wild-type ES cells and that inhibition of phosphoinositol-3-kinase (PI3K) in HEK293 cells elicits G(2) arrest that is a …
In addition, we found that PTEN null embryonic stem (ES) cells transit faster from the G(2)/M to the G(1) phase of the cell cycle whe …
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.
Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, Kandel ES, Lausch E, Christov K, Roninson IB. Chang BD, et al. Among authors: kandel es. Cancer Res. 1999 Aug 1;59(15):3761-7. Cancer Res. 1999. PMID: 10446993
Applications of green fluorescent protein as a marker of retroviral vectors.
Kandel ES, Chang BD, Schott B, Shtil AA, Gudkov AV, Roninson IB. Kandel ES, et al. Somat Cell Mol Genet. 1997 Sep;23(5):325-40. doi: 10.1007/BF02674280. Somat Cell Mol Genet. 1997. PMID: 9546076
Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis.
Conzen SD, Gottlob K, Kandel ES, Khanduri P, Wagner AJ, O'Leary M, Hay N. Conzen SD, et al. Among authors: kandel es. Mol Cell Biol. 2000 Aug;20(16):6008-18. doi: 10.1128/mcb.20.16.6008-6018.2000. Mol Cell Biol. 2000. PMID: 10913183 Free PMC article.
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