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Gene therapy for disc degeneration.
VadalĂ  G, Sowa GA, Kang JD. VadalĂ  G, et al. Expert Opin Biol Ther. 2007 Feb;7(2):185-96. doi: 10.1517/14712598.7.2.185. Expert Opin Biol Ther. 2007. PMID: 17250457 Review.
Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2.
Kang JD, Georgescu HI, McIntyre-Larkin L, Stefanovic-Racic M, Evans CH. Kang JD, et al. Spine (Phila Pa 1976). 1995 Nov 15;20(22):2373-8. doi: 10.1097/00007632-199511001-00001. Spine (Phila Pa 1976). 1995. PMID: 8578386
Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2.
Kang JD, Georgescu HI, McIntyre-Larkin L, Stefanovic-Racic M, Donaldson WF 3rd, Evans CH. Kang JD, et al. Spine (Phila Pa 1976). 1996 Feb 1;21(3):271-7. doi: 10.1097/00007632-199602010-00003. Spine (Phila Pa 1976). 1996. PMID: 8742201
Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases.
Kang JD, Stefanovic-Racic M, McIntyre LA, Georgescu HI, Evans CH. Kang JD, et al. Spine (Phila Pa 1976). 1997 May 15;22(10):1065-73. doi: 10.1097/00007632-199705150-00003. Spine (Phila Pa 1976). 1997. PMID: 9160463
Adenovirus-mediated gene transfer to nucleus pulposus cells. Implications for the treatment of intervertebral disc degeneration.
Nishida K, Kang JD, Suh JK, Robbins PD, Evans CH, Gilbertson LG. Nishida K, et al. Spine (Phila Pa 1976). 1998 Nov 15;23(22):2437-42; discussion 2443. doi: 10.1097/00007632-199811150-00016. Spine (Phila Pa 1976). 1998. PMID: 9836359
Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene.
Nishida K, Kang JD, Gilbertson LG, Moon SH, Suh JK, Vogt MT, Robbins PD, Evans CH. Nishida K, et al. Spine (Phila Pa 1976). 1999 Dec 1;24(23):2419-25. doi: 10.1097/00007632-199912010-00002. Spine (Phila Pa 1976). 1999. PMID: 10626303
Spine update: potential applications of gene therapy to the treatment of spinal disorders.
Nishida K, Gilbertson LG, Evans CH, Kang JD. Nishida K, et al. Spine (Phila Pa 1976). 2000 May 15;25(10):1308-14. doi: 10.1097/00007632-200005150-00021. Spine (Phila Pa 1976). 2000. PMID: 10806514 Review. No abstract available.
Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders.
Moon SH, Gilbertson LG, Nishida K, Knaub M, Muzzonigro T, Robbins PD, Evans CH, Kang JD. Moon SH, et al. Spine (Phila Pa 1976). 2000 Oct 15;25(20):2573-9. doi: 10.1097/00007632-200010150-00006. Spine (Phila Pa 1976). 2000. PMID: 11034640
Potential applications of gene therapy to the treatment of intervertebral disc disorders.
Nishida K, Gilbertson LG, Robbins PD, Evans CH, Kang JD. Nishida K, et al. Clin Orthop Relat Res. 2000 Oct;(379 Suppl):S234-41. doi: 10.1097/00003086-200010001-00031. Clin Orthop Relat Res. 2000. PMID: 11039775 Review.
Orthopaedic gene therapy. Spine.
Kang JD, Boden SD. Kang JD, et al. Clin Orthop Relat Res. 2000 Oct;(379 Suppl):S256-9. Clin Orthop Relat Res. 2000. PMID: 11039778 No abstract available.
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