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Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.
Park MT, Choi JA, Kim MJ, Um HD, Bae S, Kang CM, Cho CK, Kang S, Chung HY, Lee YS, Lee SJ. Park MT, et al. Among authors: kang s, kang cm. J Biol Chem. 2003 Dec 12;278(50):50624-34. doi: 10.1074/jbc.M309011200. Epub 2003 Sep 30. J Biol Chem. 2003. PMID: 14522966 Free article.
Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release.
Park MT, Kim MJ, Kang YH, Choi SY, Lee JH, Choi JA, Kang CM, Cho CK, Kang S, Bae S, Lee YS, Chung HY, Lee SJ. Park MT, et al. Among authors: kang s, kang cm, kang yh. Blood. 2005 Feb 15;105(4):1724-33. doi: 10.1182/blood-2004-07-2938. Epub 2004 Oct 14. Blood. 2005. PMID: 15486061 Free article.
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