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Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases.
Shimizu M, Gruz P, Kamiya H, Kim SR, Pisani FM, Masutani C, Kanke Y, Harashima H, Hanaoka F, Nohmi T. Shimizu M, et al. Among authors: Kanke Y. EMBO Rep. 2003 Mar;4(3):269-73. doi: 10.1038/sj.embor.embor765. EMBO Rep. 2003. PMID: 12634844 Free PMC article.
Thus, our results suggest that the Y-family DNA polymerases promote mutagenesis through the erroneous incorporation of oxidized dNTPs during DNA synthesis, in addition to facilitating translesion DNA synthesis. We also report that human DNA polymerase eta, a human Y-family DNA polymerase, incorporates the oxidized dNTPs in a similar erroneous manner....
Thus, our results suggest that the Y-family DNA polymerases promote mutagenesis through the erroneous incorporation of oxidized dNTPs …
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