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Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model.
Siveen KS, Mustafa N, Li F, Kannaiyan R, Ahn KS, Kumar AP, Chng WJ, Sethi G. Siveen KS, et al. Among authors: kannaiyan r. Oncotarget. 2014 Feb 15;5(3):634-48. doi: 10.18632/oncotarget.1596. Oncotarget. 2014. PMID: 24504138 Free PMC article.
Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo.
Rajendran P, Li F, Shanmugam MK, Kannaiyan R, Goh JN, Wong KF, Wang W, Khin E, Tergaonkar V, Kumar AP, Luk JM, Sethi G. Rajendran P, et al. Among authors: kannaiyan r. Cancer Prev Res (Phila). 2012 Apr;5(4):631-43. doi: 10.1158/1940-6207.CAPR-11-0420. Epub 2012 Feb 27. Cancer Prev Res (Phila). 2012. PMID: 22369852 Free article.
Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4.
Manu KA, Shanmugam MK, Rajendran P, Li F, Ramachandran L, Hay HS, Kannaiyan R, Swamy SN, Vali S, Kapoor S, Ramesh B, Bist P, Koay ES, Lim LH, Ahn KS, Kumar AP, Sethi G. Manu KA, et al. Among authors: kannaiyan r. Mol Cancer. 2011 Sep 1;10:107. doi: 10.1186/1476-4598-10-107. Mol Cancer. 2011. PMID: 21880153 Free PMC article.
Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways.
Kannaiyan R, Manu KA, Chen L, Li F, Rajendran P, Subramaniam A, Lam P, Kumar AP, Sethi G. Kannaiyan R, et al. Apoptosis. 2011 Oct;16(10):1028-41. doi: 10.1007/s10495-011-0629-6. Apoptosis. 2011. PMID: 21786165
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.
Kannaiyan R, Hay HS, Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Chng WJ, Sethi G. Kannaiyan R, et al. Br J Pharmacol. 2011 Nov;164(5):1506-21. doi: 10.1111/j.1476-5381.2011.01449.x. Br J Pharmacol. 2011. PMID: 21506956 Free PMC article.
Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma.
Shanmugam MK, Ahn KS, Lee JH, Kannaiyan R, Mustafa N, Manu KA, Siveen KS, Sethi G, Chng WJ, Kumar AP. Shanmugam MK, et al. Among authors: kannaiyan r. Front Pharmacol. 2018 May 3;9:365. doi: 10.3389/fphar.2018.00365. eCollection 2018. Front Pharmacol. 2018. PMID: 29773987 Free PMC article.
A comprehensive review of protein kinase inhibitors for cancer therapy.
Kannaiyan R, Mahadevan D. Kannaiyan R, et al. Expert Rev Anticancer Ther. 2018 Dec;18(12):1249-1270. doi: 10.1080/14737140.2018.1527688. Epub 2018 Oct 9. Expert Rev Anticancer Ther. 2018. PMID: 30259761 Free PMC article. Review.
A Comparative Analysis of Tumors and Plasma Circulating Tumor DNA in 145 Advanced Cancer Patients Annotated by 3 Core Cellular Processes.
Larson K, Kannaiyan R, Pandey R, Chen Y, Babiker HM, Mahadevan D. Larson K, et al. Among authors: kannaiyan r. Cancers (Basel). 2020 Mar 16;12(3):701. doi: 10.3390/cancers12030701. Cancers (Basel). 2020. PMID: 32188081 Free PMC article.
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