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Intracutaneous injection of the macrophage-activating lipopeptide-2 (MALP-2) which accelerates wound healing in mice--a phase I trial in 12 patients.
Niebuhr M, Mühlradt PF, Wittmann M, Kapp A, Werfel T. Niebuhr M, et al. Among authors: kapp a. Exp Dermatol. 2008 Dec;17(12):1052-6. doi: 10.1111/j.1600-0625.2008.00750.x. Exp Dermatol. 2008. PMID: 18713273 Clinical Trial.
Chronic skin ulcers, such as leg ulcers, pressure sores and diabetic foot ulcers, are a challenge to physicians and medical personnel and a cause of tremendous discomfort and ensuing loss of quality of life to the patients. ...An artificial wound was created with …
Chronic skin ulcers, such as leg ulcers, pressure sores and diabetic foot ulcers, are a challenge to physicians and medical personnel …
Ultraviolet radiation effects on human keratinocyte ICAM-1 expression: UV-induced inhibition of cytokine-induced ICAM-1 mRNA expression is transient, differentially restored for IFN gamma versus TNF alpha, and followed by ICAM-1 induction via a TNF alpha-like pathway.
Krutmann J, Czech W, Parlow F, Trefzer U, Kapp A, Schöpf E, Luger TA. Krutmann J, et al. Among authors: kapp a. J Invest Dermatol. 1992 Jun;98(6):923-8. doi: 10.1111/1523-1747.ep12460737. J Invest Dermatol. 1992. PMID: 1350607
After a 12-h incubation period, however, IFN gamma responsiveness was found to be restored in irradiated cells, whereas restoration of responsiveness to TNF alpha required at least a 24-h recovery phase. ...Moreover, UV itself is able to induce ICAM-1 mRNA expressio …
After a 12-h incubation period, however, IFN gamma responsiveness was found to be restored in irradiated cells, whereas restoration o …
Human epidermal keratinocytes are a source of soluble ICAM-1 molecules.
Budnik A, Trefzer U, Parlow F, Grewe M, Kapp A, Schöpf E, Krutmann J. Budnik A, et al. Among authors: kapp a. Exp Dermatol. 1992 Jul;1(1):27-30. doi: 10.1111/j.1600-0625.1992.tb00068.x. Exp Dermatol. 1992. PMID: 1364253
A soluble form of the usually membrane-bound adhesion molecule ICAM-1 was detected in supernatants derived from human epidermal keratinocytes. ...In addition, constitutive shedding of sICAM-1 by transformed human keratinocytes may represent a possible mechanism by w
A soluble form of the usually membrane-bound adhesion molecule ICAM-1 was detected in supernatants derived from human epidermal kerat
High-dose UVA1 therapy in the treatment of patients with atopic dermatitis.
Krutmann J, Czech W, Diepgen T, Niedner R, Kapp A, Schöpf E. Krutmann J, et al. Among authors: kapp a. J Am Acad Dermatol. 1992 Feb;26(2 Pt 1):225-30. doi: 10.1016/0190-9622(92)70031-a. J Am Acad Dermatol. 1992. PMID: 1552057 Clinical Trial.
RESULTS: High-dose UVA1 irradiation was found to induce a significant clinical improvement of atopic dermatitis (p less than 0.001). ...CONCLUSION: These studies indicate that high-dose UVA1 irradiation may represent a novel phototherapeutic modality for the treatme …
RESULTS: High-dose UVA1 irradiation was found to induce a significant clinical improvement of atopic dermatitis (p less than 0.001). …
Serum eosinophil cationic protein (ECP) is a sensitive measure for disease activity in atopic dermatitis.
Czech W, Krutmann J, Schöpf E, Kapp A. Czech W, et al. Among authors: kapp a. Br J Dermatol. 1992 Apr;126(4):351-5. doi: 10.1111/j.1365-2133.1992.tb00677.x. Br J Dermatol. 1992. PMID: 1571256
In addition, there was a significant correlation between serum ECP and the clinical score (R = 0.67, P less than or equal to 0.001). These data indicate that serum ECP may be a helpful tool for monitoring disease activity in AD....
In addition, there was a significant correlation between serum ECP and the clinical score (R = 0.67, P less than or equal to 0.001). …
Interleukin-5-induced granulocyte activation in atopic patients.
Kapp A, Zeck-Kapp G. Kapp A, et al. Br J Dermatol. 1991 Aug;125(2):108-15. doi: 10.1111/j.1365-2133.1991.tb06056.x. Br J Dermatol. 1991. PMID: 1911293
A significant direct effect of both human and murine IL-5 on granulocyte oxidative metabolism could only be detected in those patients with AD and allergic rhinitis. ...
A significant direct effect of both human and murine IL-5 on granulocyte oxidative metabolism could only be detected in those patient
Increased IL-6 production by monocytes and keratinocytes in patients with psoriasis.
Neuner P, Urbanski A, Trautinger F, Möller A, Kirnbauer R, Kapp A, Schöpf E, Schwarz T, Luger TA. Neuner P, et al. Among authors: kapp a. J Invest Dermatol. 1991 Jul;97(1):27-33. doi: 10.1111/1523-1747.ep12477880. J Invest Dermatol. 1991. PMID: 2056189
Interleukin-6 (IL-6) is a multifunctional inflammatory cytokine that is produced by monocytes and keratinocytes upon stimulation. Because psoriasis is a skin disease characterized by a hyperproliferative activity of keratinocytes and an inflammatory infiltrat …
Interleukin-6 (IL-6) is a multifunctional inflammatory cytokine that is produced by monocytes and keratinocytes upon stimulation. Bec …
The chemokine RANTES is more than a chemoattractant: characterization of its effect on human eosinophil oxidative metabolism and morphology in comparison with IL-5 and GM-CSF.
Kapp A, Zeck-Kapp G, Czech W, Schöpf E. Kapp A, et al. J Invest Dermatol. 1994 Jun;102(6):906-14. doi: 10.1111/1523-1747.ep12383399. J Invest Dermatol. 1994. PMID: 7516398
Eosinophils were shown to play a major role in the allergic inflammatory process leading to the clinical symptoms of atopic dermatitis. Only selected cytokines are capable of inducing a chemotactic response in eosinophils. In particular, the chemokine RANTES was rec …
Eosinophils were shown to play a major role in the allergic inflammatory process leading to the clinical symptoms of atopic dermatiti …
Activation of the respiratory burst in human eosinophils by chemotaxins requires intracellular calcium fluxes.
Elsner J, Dichmann S, Kapp A. Elsner J, et al. Among authors: kapp a. J Invest Dermatol. 1995 Aug;105(2):231-6. doi: 10.1111/1523-1747.ep12317519. J Invest Dermatol. 1995. PMID: 7636306
This suggested a Ca(++)-sensitive form of protein kinase C in the activation process of the respiratory burst. These data demonstrate that intracellular and extracellular calcium represent a prerequisite of chemotaxin-induced activation of the respiratory burst in h …
This suggested a Ca(++)-sensitive form of protein kinase C in the activation process of the respiratory burst. These data demonstrate …
Phorbol-12-myristate-13-acetate-treated human keratinocytes express B7-like molecules that serve a costimulatory role in T-cell activation.
Augustin M, Dietrich A, Niedner R, Kapp A, Schöpf E, Ledbetter JA, Brady W, Linsley PS, Simon JC. Augustin M, et al. Among authors: kapp a. J Invest Dermatol. 1993 Mar;100(3):275-81. doi: 10.1111/1523-1747.ep12469748. J Invest Dermatol. 1993. PMID: 7680055
By contrast, PMA induced a dose-dependent upregulation of B7 staining. This staining identifies a molecule closely related to B7 because it was blocked by purified recombinant B7 immunoglobulin. ...We conclude that PMA upregulates on HNK the expression of a B …
By contrast, PMA induced a dose-dependent upregulation of B7 staining. This staining identifies a molecule closely related to …
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