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Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine.
Sharma S, Schmid MA, Sanchez Felipe L, Grenelle J, Kaptein SJF, Coelmont L, Neyts J, Dallmeier K. Sharma S, et al. Among authors: kaptein sjf. Hum Vaccin Immunother. 2020 Jun 23:1-8. doi: 10.1080/21645515.2020.1765621. Online ahead of print. Hum Vaccin Immunother. 2020. PMID: 32574095
Reverse engineering synthetic antiviral amyloids.
Michiels E, Roose K, Gallardo R, Khodaparast L, Khodaparast L, van der Kant R, Siemons M, Houben B, Ramakers M, Wilkinson H, Guerreiro P, Louros N, Kaptein SJF, Ibañez LI, Smet A, Baatsen P, Liu S, Vorberg I, Bormans G, Neyts J, Saelens X, Rousseau F, Schymkowitz J. Michiels E, et al. Among authors: kaptein sjf. Nat Commun. 2020 Jun 5;11(1):2832. doi: 10.1038/s41467-020-16721-8. Nat Commun. 2020. PMID: 32504029 Free PMC article.
Design, Synthesis and Discovery of N,N'-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication.
Spizzichino S, Mattedi G, Lauder K, Valle C, Aouadi W, Canard B, Decroly E, Kaptein SJF, Neyts J, Graham C, Sule Z, Barlow DJ, Silvestri R, Castagnolo D. Spizzichino S, et al. Among authors: kaptein sjf. ChemMedChem. 2020 Feb 17;15(4):385-390. doi: 10.1002/cmdc.201900533. Epub 2020 Jan 7. ChemMedChem. 2020. PMID: 31805205 Free PMC article.
ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas.
Wilder-Smith A, Preet R, Brickley EB, Ximenes RAA, Miranda-Filho DB, Turchi Martelli CM, Araújo TVB, Montarroyos UR, Moreira ME, Turchi MD, Solomon T, Jacobs BC, Villamizar CP, Osorio L, de Filipps AMB, Neyts J, Kaptein S, Huits R, Ariën KK, Willison HJ, Edgar JM, Barnett SC, Peeling R, Boeras D, Guzman MG, de Silva AM, Falconar AK, Romero-Vivas C, Gaunt MW, Sette A, Weiskopf D, Lambrechts L, Dolk H, Morris JK, Orioli IM, O'Reilly KM, Yakob L, Rocklöv J, Soares C, Ferreira MLB, Franca RFO, Precioso AR, Logan J, Lang T, Jamieson N, Massad E. Wilder-Smith A, et al. Among authors: kaptein s. Glob Health Action. 2019;12(1):1666566. doi: 10.1080/16549716.2019.1666566. Glob Health Action. 2019. PMID: 31640505 Free PMC article.
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.
Vincetti P, Kaptein SJF, Costantino G, Neyts J, Radi M. Vincetti P, et al. Among authors: kaptein sjf. ACS Med Chem Lett. 2019 Jan 23;10(4):558-563. doi: 10.1021/acsmedchemlett.8b00583. eCollection 2019 Apr 11. ACS Med Chem Lett. 2019. PMID: 30996796 Free PMC article.
Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals.
Tricot T, Helsen N, Kaptein SJF, Neyts J, Verfaillie CM. Tricot T, et al. Among authors: kaptein sjf. PLoS One. 2018 Dec 19;13(12):e0209097. doi: 10.1371/journal.pone.0209097. eCollection 2018. PLoS One. 2018. PMID: 30566505 Free PMC article.
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