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Protective role of three vegetable peels in alloxan induced diabetes mellitus in male mice.
Dixit Y, Kar A. Dixit Y, et al. Plant Foods Hum Nutr. 2010 Sep;65(3):284-9. doi: 10.1007/s11130-010-0175-3. Plant Foods Hum Nutr. 2010. PMID: 20614191
In a preliminary study, effects of ethanolic extracts of Cucurbita pepo, Cucumis sativus and Praecitrullus fistulosus peels were studied at 250 and 500 mg kg(-1) d(-1) for 15 days in the alterations in serum glucose and in hepatic lipid peroxidation (LPO) in male mice. ...
In a preliminary study, effects of ethanolic extracts of Cucurbita pepo, Cucumis sativus and Praecitrullus fistulosus peels were stud …
Protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside, isolated from Annona squamosa leaves in thyrotoxicosis and in hepatic lipid peroxidation in rats.
Panda S, Kar A. Panda S, et al. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5726-8. doi: 10.1016/j.bmcl.2015.10.090. Epub 2015 Oct 30. Bioorg Med Chem Lett. 2015. PMID: 26547692
Administration of l-T4 at 500μg/kg body weight for 12days increased the levels of serum thyroid hormones, the activity of 5'-monodeiodinase-I (5'DI) and hepatic glucose-6-phosphatase (G-6Pase) as well as lipid peroxidation (LPO); with a parallel decrease in the levels of c …
Administration of l-T4 at 500μg/kg body weight for 12days increased the levels of serum thyroid hormones, the activity of 5'-monodeiodinase- …
Role of a gitogenin-type steroidal saponin (3-O-β-d-glucopyranosyl (1→2)-β-d-glucopyranosyl (1→4)-β-d-galactopyranoside-25R,5α-spirostane-2α,3β-diol), isolated from the leaves of Malvastrum coromandelianum in regulating thyrotoxicosis in rats.
Panda S, Kar A. Panda S, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4804-4807. doi: 10.1016/j.bmcl.2016.08.025. Epub 2016 Aug 10. Bioorg Med Chem Lett. 2016. PMID: 27561715
The hitherto unknown role of saponin in the regulation of thyrotoxicosis has been revealed in chemically-induced thyrotoxic rats. l-T4 (l-thyroxine) administration at pre-standardized dose of 500-μg/kg body weight for 12days increased the levels of thyroid hormones, enhanced the …
The hitherto unknown role of saponin in the regulation of thyrotoxicosis has been revealed in chemically-induced thyrotoxic rats. l-T4 (l-th …
Towards further understanding on the antioxidative activities of Prunus persica fruit: a comparative study with four different fractions.
Dhingra N, Sharma R, Kar A. Dhingra N, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Nov 11;132:582-7. doi: 10.1016/j.saa.2014.05.008. Epub 2014 May 15. Spectrochim Acta A Mol Biomol Spectrosc. 2014. PMID: 24892537
A significantly high correlation coefficient existed between total antioxidant activities and with total phenolic as well as total flavonoid contents. ...
A significantly high correlation coefficient existed between total antioxidant activities and with total phenolic as well as total fl
Possible amelioration of atherogenic diet induced dyslipidemia, hypothyroidism and hyperglycemia by the peel extracts of Mangifera indica, Cucumis melo and Citrullus vulgaris fruits in rats.
Parmar HS, Kar A. Parmar HS, et al. Biofactors. 2008;33(1):13-24. doi: 10.1002/biof.5520330102. Biofactors. 2008. PMID: 19276533
A phytochemical analysis indicated the presence of a high amount of polyphenols and ascorbic acid in the test peel extracts suggesting that the beneficial effects could be the result of the rich content of polyphenols and ascorbic acid in the studied peels....
A phytochemical analysis indicated the presence of a high amount of polyphenols and ascorbic acid in the test peel extracts su
Periplogenin-3-O- -D-glucopyranosyl -(1-->6)- -D-glucopyaranosyl- -(1-->4) -D-cymaropyranoside, isolated from Aegle marmelos protects doxorubicin induced cardiovascular problems and hepatotoxicity in rats.
Panda S, Kar A. Panda S, et al. Cardiovasc Ther. 2009 Summer;27(2):108-16. doi: 10.1111/j.1755-5922.2009.00078.x. Cardiovasc Ther. 2009. PMID: 19426248
Doxorubicin is a common chemotherapeutic anticancer drug. Its use is associated with adverse effects including cardiotoxicity. ...The isolated periplogenin from the leaves of A. marmelos could potentially inhibit doxorubicin-induced cardiovascular problems in rats. …
Doxorubicin is a common chemotherapeutic anticancer drug. Its use is associated with adverse effects including cardiotoxicity. ...The …
Chavibetol corrects thyrotoxicosis through alterations in thyroid peroxidase.
Panda S, Sharma R, Kar A. Panda S, et al. Naunyn Schmiedebergs Arch Pharmacol. 2019 May;392(5):541-550. doi: 10.1007/s00210-018-01606-x. Epub 2019 Jan 4. Naunyn Schmiedebergs Arch Pharmacol. 2019. PMID: 30610248
Thyrotoxicosis is a clinical syndrome that commonly results from excess secretion and/or release of thyroid hormones in the circulation. ...Effects of CHV were more or less similar to a conventional antithyroid drug, propylthiouracil (PTU)....
Thyrotoxicosis is a clinical syndrome that commonly results from excess secretion and/or release of thyroid hormones in the circulati …
Pyrroloquinoline quinone (PQQ) has potential to ameliorate streptozotocin-induced diabetes mellitus and oxidative stress in mice: A histopathological and biochemical study.
Kumar N, Kar A. Kumar N, et al. Chem Biol Interact. 2015 Oct 5;240:278-90. doi: 10.1016/j.cbi.2015.08.027. Epub 2015 Sep 4. Chem Biol Interact. 2015. PMID: 26343954
Animals of groups III-VI were rendered diabetic by single dose of streptozotocin (STZ, 150 mg/kg body weight), following which PQQ at a dose of 5, 10 and 20 mg/kg, was injected to the animals of group IV, V and VI respectively for 15 days. ...STZ-treated animals developed …
Animals of groups III-VI were rendered diabetic by single dose of streptozotocin (STZ, 150 mg/kg body weight), following which PQQ at a
Combined Effects of Vincristine and Quercetin in Reducing Isoproterenol-Induced Cardiac Necrosis in Rats.
Panda S, Kar A. Panda S, et al. Cardiovasc Toxicol. 2015 Oct;15(4):291-9. doi: 10.1007/s12012-014-9291-x. Cardiovasc Toxicol. 2015. PMID: 25537132
However, treatment of both vincristine and quercetin for a similar period reduced the serum CK-MB, LDH, SGPT and cTnT levels near to normal levels in ISO-treated rats. ...In conclusion, the present finding appears to be the first one, suggesting a better protection …
However, treatment of both vincristine and quercetin for a similar period reduced the serum CK-MB, LDH, SGPT and cTnT levels near to …
Pyrroloquinoline quinone ameliorates oxidative stress and lipid peroxidation in the brain of streptozotocin-induced diabetic mice.
Kumar N, Kar A. Kumar N, et al. Can J Physiol Pharmacol. 2015 Jan;93(1):71-9. doi: 10.1139/cjpp-2014-0270. Can J Physiol Pharmacol. 2015. PMID: 25474723
Pyrroloquinoline quinone (PQQ) is believed to be a strong antioxidant, as it protects cells from oxidative damage. In this study, we elucidated the hitherto unknown potential of PQQ to ameliorate the brain damage caused by diabetes mellitus and the associated hyperglycemia …
Pyrroloquinoline quinone (PQQ) is believed to be a strong antioxidant, as it protects cells from oxidative damage. In this study, we …
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