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Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.
ACS Cent Sci. 2018.
PMID: 30648156
Free PMC article.
Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.
Urban DJ, Martinez NJ, Davis MI, Brimacombe KR, Cheff DM, Lee TD, Henderson MJ, Titus SA, Pragani R, Rohde JM, Liu L, Fang Y, Karavadhi S, Shah P, Lee OW, Wang A, McIver A, Zheng H, Wang X, Xu X, Jadhav A, Simeonov A, Shen M, Boxer MB, Hall MD.
Urban DJ, et al. Among authors: karavadhi s.
Sci Rep. 2017 Oct 6;7(1):12758. doi: 10.1038/s41598-017-12630-x.
Sci Rep. 2017.
PMID: 28986582
Free PMC article.
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Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
Rohde JM, Karavadhi S, Pragani R, Liu L, Fang Y, Zhang W, McIver A, Zheng H, Liu Q, Davis MI, Urban DJ, Lee TD, Cheff DM, Hollingshead M, Henderson MJ, Martinez NJ, Brimacombe KR, Yasgar A, Zhao W, Klumpp-Thomas C, Michael S, Covey J, Moore WJ, Stott GM, Li Z, Simeonov A, Jadhav A, Frye S, Hall MD, Shen M, Wang X, Patnaik S, Boxer MB.
Rohde JM, et al. Among authors: karavadhi s.
J Med Chem. 2021 Apr 22;64(8):4913-4946. doi: 10.1021/acs.jmedchem.1c00019. Epub 2021 Apr 6.
J Med Chem. 2021.
PMID: 33822623
Free PMC article.
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Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen.
Clausse V, Fang Y, Tao D, Tagad HD, Sun H, Wang Y, Karavadhi S, Lane K, Shi ZD, Vasalatiy O, LeClair CA, Eells R, Shen M, Patnaik S, Appella E, Coussens NP, Hall MD, Appella DH.
Clausse V, et al. Among authors: karavadhi s.
ACS Pharmacol Transl Sci. 2022 Sep 28;5(10):993-1006. doi: 10.1021/acsptsci.2c00147. eCollection 2022 Oct 14.
ACS Pharmacol Transl Sci. 2022.
PMID: 36268125
Free PMC article.
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Virtual Screening for the Discovery of Microbiome β-Glucuronidase Inhibitors to Alleviate Cancer Drug Toxicity.
Challa AP, Hu X, Zhang YQ, Hymes J, Wallace BD, Karavadhi S, Sun H, Patnaik S, Hall MD, Shen M.
Challa AP, et al. Among authors: karavadhi s.
J Chem Inf Model. 2022 Apr 11;62(7):1783-1793. doi: 10.1021/acs.jcim.1c01414. Epub 2022 Mar 31.
J Chem Inf Model. 2022.
PMID: 35357819
Free PMC article.
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Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.
Liu L, Tang M, Pragani R, Whitby FG, Zhang YQ, Balakrishnan B, Fang Y, Karavadhi S, Tao D, LeClair CA, Hall MD, Marugan JJ, Boxer M, Shen M, Hill CP, Lai K, Patnaik S.
Liu L, et al. Among authors: karavadhi s.
J Med Chem. 2021 Sep 23;64(18):13551-13571. doi: 10.1021/acs.jmedchem.1c00945. Epub 2021 Sep 7.
J Med Chem. 2021.
PMID: 34491744
Free PMC article.
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An electrophilic fragment screening for the development of small molecules targeting caspase-2.
Cuellar ME, Yang M, Karavadhi S, Zhang YQ, Zhu H, Sun H, Shen M, Hall MD, Patnaik S, Ashe KH, Walters MA, Pockes S.
Cuellar ME, et al. Among authors: karavadhi s.
Eur J Med Chem. 2023 Nov 5;259:115632. doi: 10.1016/j.ejmech.2023.115632. Epub 2023 Jul 11.
Eur J Med Chem. 2023.
PMID: 37453329
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