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Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).
Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR. Webster SP, et al. Among authors: sooy k. Br J Pharmacol. 2017 Mar;174(5):396-408. doi: 10.1111/bph.13699. Epub 2017 Jan 25. Br J Pharmacol. 2017. PMID: 28012176 Free PMC article. Clinical Trial.
Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.
Webster SP, Ward P, Binnie M, Craigie E, McConnell KM, Sooy K, Vinter A, Seckl JR, Walker BR. Webster SP, et al. Among authors: sooy k. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. doi: 10.1016/j.bmcl.2007.02.057. Epub 2007 Feb 25. Bioorg Med Chem Lett. 2007. PMID: 17350260
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