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12 results
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Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).
Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF, Taketo MM. Oshima M, et al. Among authors: kargman sl. Cell. 1996 Nov 29;87(5):803-9. doi: 10.1016/s0092-8674(00)81988-1. Cell. 1996. PMID: 8945508 Free article.
Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma.
Robichaud A, Tuck SA, Kargman S, Tam J, Wong E, Abramovitz M, Mortimer JR, Burston HE, Masson P, Hirota J, Slipetz D, Kennedy B, O'Neill G, Xanthoudakis S. Robichaud A, et al. Am J Respir Cell Mol Biol. 2005 Sep;33(3):303-14. doi: 10.1165/rcmb.2004-0372OC. Epub 2005 Jun 9. Am J Respir Cell Mol Biol. 2005. PMID: 15947424
Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
Chan CC, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Ford-Hutchinson AW, Forrest MJ, Gauthier JY, Gordon R, Gresser M, Guay J, Kargman S, Kennedy B, Leblanc Y, Leger S, Mancini J, O'Neill GP, Ouellet M, Patrick D, Percival MD, Perrier H, Prasit P, Rodger I, et al. Chan CC, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):551-60. J Pharmacol Exp Ther. 1999. PMID: 10411562
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
Riendeau D, Percival MD, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Falgueyret JP, Ford-Hutchinson AW, Gordon R, Greig G, Gresser M, Guay J, Kargman S, Léger S, Mancini JA, O'Neill G, Ouellet M, Rodger IW, Thérien M, Wang Z, Webb JK, Wong E, Chan CC, et al. Riendeau D, et al. Br J Pharmacol. 1997 May;121(1):105-17. doi: 10.1038/sj.bjp.0701076. Br J Pharmacol. 1997. PMID: 9146894 Free PMC article.
Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells.
Wong E, DeLuca C, Boily C, Charleson S, Cromlish W, Denis D, Kargman S, Kennedy BP, Ouellet M, Skorey K, O'Neill GP, Vickers PJ, Riendeau D. Wong E, et al. Inflamm Res. 1997 Feb;46(2):51-9. doi: 10.1007/s000110050063. Inflamm Res. 1997. PMID: 9085144
Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells.
Kargman S, Wong E, Greig GM, Falgueyret JP, Cromlish W, Ethier D, Yergey JA, Riendeau D, Evans JF, Kennedy B, Tagari P, Francis DA, O'Neill GP. Kargman S, et al. Biochem Pharmacol. 1996 Oct 11;52(7):1113-25. doi: 10.1016/0006-2952(96)00462-5. Biochem Pharmacol. 1996. PMID: 8831731
Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts.
Kargman S, Charleson S, Cartwright M, Frank J, Riendeau D, Mancini J, Evans J, O'Neill G. Kargman S, et al. Gastroenterology. 1996 Aug;111(2):445-54. doi: 10.1053/gast.1996.v111.pm8690211. Gastroenterology. 1996. PMID: 8690211
A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells.
Kargman S, Vickers PJ, Evans JF. Kargman S, et al. J Cell Biol. 1992 Dec;119(6):1701-9. doi: 10.1083/jcb.119.6.1701. J Cell Biol. 1992. PMID: 1469057 Free PMC article.
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
Lau CK, Brideau C, Chan CC, Charleson S, Cromlish WA, Ethier D, Gauthier JY, Gordon R, Guay J, Kargman S, Li CS, Prasit P, Riendeau D, Thérien M, Visco DM, Xu L. Lau CK, et al. Bioorg Med Chem Lett. 1999 Nov 15;9(22):3187-92. doi: 10.1016/s0960-894x(99)00560-0. Bioorg Med Chem Lett. 1999. PMID: 10576685
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
Prasit P, Wang Z, Brideau C, Chan CC, Charleson S, Cromlish W, Ethier D, Evans JF, Ford-Hutchinson AW, Gauthier JY, Gordon R, Guay J, Gresser M, Kargman S, Kennedy B, Leblanc Y, Léger S, Mancini J, O'Neill GP, Ouellet M, Percival MD, Perrier H, Riendeau D, Rodger I, Zamboni R, et al. Prasit P, et al. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1773-8. doi: 10.1016/s0960-894x(99)00288-7. Bioorg Med Chem Lett. 1999. PMID: 10406640
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