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Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed.
Absalom NL, Quek G, Lewis TM, Qudah T, von Arenstorff I, Ambrus JI, Harpsøe K, Karim N, Balle T, McLeod MD, Chebib M. Absalom NL, et al. Among authors: karim n. J Biol Chem. 2013 Sep 13;288(37):26521-32. doi: 10.1074/jbc.M113.475053. Epub 2013 Jul 26. J Biol Chem. 2013. PMID: 23893416 Free PMC article.
α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB).
Absalom N, Eghorn LF, Villumsen IS, Karim N, Bay T, Olsen JV, Knudsen GM, Bräuner-Osborne H, Frølund B, Clausen RP, Chebib M, Wellendorph P. Absalom N, et al. Among authors: karim n. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13404-9. doi: 10.1073/pnas.1204376109. Epub 2012 Jul 2. Proc Natl Acad Sci U S A. 2012. PMID: 22753476 Free PMC article.
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