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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.
Benilova I, Karran E, De Strooper B. Benilova I, et al. Nat Neurosci. 2012 Jan 29;15(3):349-57. doi: 10.1038/nn.3028. Nat Neurosci. 2012. PMID: 22286176 Review.
The amyloid cascade hypothesis: are we poised for success or failure?
Karran E, De Strooper B. Karran E, et al. J Neurochem. 2016 Oct;139 Suppl 2:237-252. doi: 10.1111/jnc.13632. Epub 2016 Jun 3. J Neurochem. 2016. PMID: 27255958 Review.
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.
Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, De Strooper B. Chávez-Gutiérrez L, et al. EMBO J. 2012 May 16;31(10):2261-74. doi: 10.1038/emboj.2012.79. Epub 2012 Apr 13. EMBO J. 2012. PMID: 22505025 Free PMC article.
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B. Serneels L, et al. Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19. Science. 2009. PMID: 19299585 Free PMC article.
Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.
Zhou L, Chávez-Gutiérrez L, Bockstael K, Sannerud R, Annaert W, May PC, Karran E, De Strooper B. Zhou L, et al. J Biol Chem. 2011 Mar 11;286(10):8677-87. doi: 10.1074/jbc.M110.194860. Epub 2011 Jan 5. J Biol Chem. 2011. PMID: 21209097 Free PMC article.
The Cellular Phase of Alzheimer's Disease.
De Strooper B, Karran E. De Strooper B, et al. Cell. 2016 Feb 11;164(4):603-15. doi: 10.1016/j.cell.2015.12.056. Cell. 2016. PMID: 26871627 Review.
Precision pharmacology for Alzheimer's disease.
Hampel H, Vergallo A, Aguilar LF, Benda N, Broich K, Cuello AC, Cummings J, Dubois B, Federoff HJ, Fiandaca M, Genthon R, Haberkamp M, Karran E, Mapstone M, Perry G, Schneider LS, Welikovitch LA, Woodcock J, Baldacci F, Lista S; Alzheimer Precision Medicine Initiative (APMI). Hampel H, et al. Pharmacol Res. 2018 Apr;130:331-365. doi: 10.1016/j.phrs.2018.02.014. Epub 2018 Feb 16. Pharmacol Res. 2018. PMID: 29458203 Review.
Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease.
Van Broeck B, Chen JM, Tréton G, Desmidt M, Hopf C, Ramsden N, Karran E, Mercken M, Rowley A. Van Broeck B, et al. Br J Pharmacol. 2011 May;163(2):375-89. doi: 10.1111/j.1476-5381.2011.01207.x. Br J Pharmacol. 2011. PMID: 21232036 Free PMC article.
Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment.
Culvenor JG, Maher F, Evin G, Malchiodi-Albedi F, Cappai R, Underwood JR, Davis JB, Karran EH, Roberts GW, Beyreuther K, Masters CL. Culvenor JG, et al. J Neurosci Res. 1997 Sep 15;49(6):719-31. doi: 10.1002/(SICI)1097-4547(19970915)49:6<719::AID-JNR6>3.0.CO;2-A. J Neurosci Res. 1997. PMID: 9335259
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