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Physiological effect and therapeutic application of alpha lipoic acid.
Park S, Karunakaran U, Jeoung NH, Jeon JH, Lee IK. Park S, et al. Among authors: karunakaran u. Curr Med Chem. 2014;21(32):3636-45. doi: 10.2174/0929867321666140706141806. Curr Med Chem. 2014. PMID: 25005184 Review.
Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes.
Karunakaran U, Kim HJ, Kim JY, Lee IK. Karunakaran U, et al. Exp Diabetes Res. 2012;2012:639762. doi: 10.1155/2012/639762. Epub 2011 Oct 1. Exp Diabetes Res. 2012. PMID: 21977023 Free PMC article. Review.
A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense.
Karunakaran U, Park KG. Karunakaran U, et al. Diabetes Metab J. 2013 Apr;37(2):106-12. doi: 10.4093/dmj.2013.37.2.106. Diabetes Metab J. 2013. PMID: 23641350 Free PMC article.
Metformin prevents glucotoxicity by alleviating oxidative and ER stress-induced CD36 expression in pancreatic beta cells.
Moon JS, Karunakaran U, Elumalai S, Lee IK, Lee HW, Kim YW, Won KC. Moon JS, et al. Among authors: karunakaran u. J Diabetes Complications. 2017 Jan;31(1):21-30. doi: 10.1016/j.jdiacomp.2016.09.001. Epub 2016 Sep 9. J Diabetes Complications. 2017. PMID: 27662780
Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells.
Elumalai S, Karunakaran U, Lee IK, Moon JS, Won KC. Elumalai S, et al. Among authors: karunakaran u. Redox Biol. 2017 Apr;11:126-134. doi: 10.1016/j.redox.2016.11.009. Epub 2016 Nov 23. Redox Biol. 2017. PMID: 27912197 Free PMC article.
Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5.
Karunakaran U, Elumalai S, Moon JS, Jeon JH, Kim ND, Park KG, Won KC, Leem J, Lee IK. Karunakaran U, et al. Diabetes Metab J. 2019 Apr;43(2):192-205. doi: 10.4093/dmj.2018.0052. Epub 2019 Jan 16. Diabetes Metab J. 2019. PMID: 30688049 Free PMC article.
CD36 dependent redoxosomes promotes ceramide-mediated pancreatic β-cell failure via p66Shc activation.
Karunakaran U, Elumalai S, Moon JS, Won KC. Karunakaran U, et al. Free Radic Biol Med. 2019 Apr;134:505-515. doi: 10.1016/j.freeradbiomed.2019.02.004. Epub 2019 Feb 5. Free Radic Biol Med. 2019. PMID: 30735834
Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin-induced β-cell apoptosis.
Karunakaran U, Park SJ, Jun do Y, Sim T, Park KG, Kim MO, Lee IK. Karunakaran U, et al. Cell Signal. 2015 Jun;27(6):1066-74. doi: 10.1016/j.cellsig.2015.01.018. Epub 2015 Feb 12. Cell Signal. 2015. PMID: 25683919
O-GlcNAc Modification: Friend or Foe in Diabetic Cardiovascular Disease.
Karunakaran U, Jeoung NH. Karunakaran U, et al. Korean Diabetes J. 2010 Aug;34(4):211-9. doi: 10.4093/kdj.2010.34.4.211. Epub 2010 Aug 31. Korean Diabetes J. 2010. PMID: 20835337 Free PMC article.
CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells.
Karunakaran U, Moon JS, Lee HW, Won KC. Karunakaran U, et al. Biochim Biophys Acta. 2015 Nov;1852(11):2414-22. doi: 10.1016/j.bbadis.2015.08.009. Epub 2015 Aug 20. Biochim Biophys Acta. 2015. PMID: 26297980
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