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Metabolic and hemodynamic effects of sodium-dependent glucose cotransporter 2 inhibitors on cardio-renal protection in the treatment of patients with type 2 diabetes mellitus.
Kashiwagi A, Maegawa H. Kashiwagi A, et al. J Diabetes Investig. 2017 Jul;8(4):416-427. doi: 10.1111/jdi.12644. Epub 2017 May 12. J Diabetes Investig. 2017. PMID: 28178390 Free PMC article. Review.
As a result, pancreatic β-cell function and peripheral insulin action significantly improve with relief from glucose toxicity. ...Although a site of action of SGLT2 inhibitors is highly specific to inhibit renal glucose reabsorption, whole-body energy metabolism, an …
As a result, pancreatic β-cell function and peripheral insulin action significantly improve with relief from glucose toxicity. ...Alt …
Improvement in in vitro insulin action after one month of insulin therapy in obese noninsulin-dependent diabetics. Measurements of glucose transport and metabolism, insulin binding, and lipolysis in isolated adipocytes.
Foley JE, Kashiwagi A, Verso MA, Reaven G, Andrews J. Foley JE, et al. Among authors: kashiwagi a. J Clin Invest. 1983 Dec;72(6):1901-9. doi: 10.1172/JCI111153. J Clin Invest. 1983. PMID: 6358258 Free PMC article.
In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus.
Kashiwagi A, Verso MA, Andrews J, Vasquez B, Reaven G, Foley JE. Kashiwagi A, et al. J Clin Invest. 1983 Oct;72(4):1246-54. doi: 10.1172/JCI111080. J Clin Invest. 1983. PMID: 6355180 Free PMC article.
However, there was a 64% decrease in the sensitivity of the glucose transport system to insulin (P less than 0.05), unrelated to concomitant changes in insulin binding. ...
However, there was a 64% decrease in the sensitivity of the glucose transport system to insulin (P less than 0.05), unrelated to conc …
Intensive Treat-to-Target Statin Therapy in High-Risk Japanese Patients With Hypercholesterolemia and Diabetic Retinopathy: Report of a Randomized Study.
Itoh H, Komuro I, Takeuchi M, Akasaka T, Daida H, Egashira Y, Fujita H, Higaki J, Hirata KI, Ishibashi S, Isshiki T, Ito S, Kashiwagi A, Kato S, Kitagawa K, Kitakaze M, Kitazono T, Kurabayashi M, Miyauchi K, Murakami T, Murohara T, Node K, Ogawa S, Saito Y, Seino Y, Shigeeda T, Shindo S, Sugawara M, Sugiyama S, Terauchi Y, Tsutsui H, Ueshima K, Utsunomiya K, Yamagishi M, Yamazaki T, Yo S, Yokote K, Yoshida K, Yoshimura M, Yoshimura N, Nakao K, Nagai R; EMPATHY Investigators. Itoh H, et al. Among authors: kashiwagi a. Diabetes Care. 2018 Jun;41(6):1275-1284. doi: 10.2337/dc17-2224. Epub 2018 Apr 6. Diabetes Care. 2018. PMID: 29626074 Clinical Trial.
The potential benefit of achieving LDL-C <70 mg/dL in a treat-to-target strategy in high-risk patients deserves further investigation....
The potential benefit of achieving LDL-C <70 mg/dL in a treat-to-target strategy in high-risk patients deserves further investigat …
Predictive properties of plasma amino acid profile for cardiovascular disease in patients with type 2 diabetes.
Kume S, Araki S, Ono N, Shinhara A, Muramatsu T, Araki H, Isshiki K, Nakamura K, Miyano H, Koya D, Haneda M, Ugi S, Kawai H, Kashiwagi A, Uzu T, Maegawa H. Kume S, et al. Among authors: kashiwagi a. PLoS One. 2014 Jun 27;9(6):e101219. doi: 10.1371/journal.pone.0101219. eCollection 2014. PLoS One. 2014. PMID: 24971671 Free PMC article.
A multivariate Cox proportional hazards regression analysis showed that the high level of CVD-AI was identified as an independent risk factor for CVD (adjusted hazard ratio: 2.86 [95% CI: 1.57-5.19]). ...
A multivariate Cox proportional hazards regression analysis showed that the high level of CVD-AI was identified as an independent ris
Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet.
Kume S, Uzu T, Araki S, Sugimoto T, Isshiki K, Chin-Kanasaki M, Sakaguchi M, Kubota N, Terauchi Y, Kadowaki T, Haneda M, Kashiwagi A, Koya D. Kume S, et al. Among authors: kashiwagi a. J Am Soc Nephrol. 2007 Oct;18(10):2715-23. doi: 10.1681/ASN.2007010089. Epub 2007 Sep 12. J Am Soc Nephrol. 2007. PMID: 17855643
Thus, a high-fat diet leads to an altered balance between renal lipogenesis and lipolysis, subsequent renal accumulation of lipid, and renal injury. We suggest that renal lipid metabolism could serve as a new therapeutic target to prevent chronic kidney disease in p …
Thus, a high-fat diet leads to an altered balance between renal lipogenesis and lipolysis, subsequent renal accumulation of lipid, an …
Structural and functional changes in the kidneys of high-fat diet-induced obese mice.
Deji N, Kume S, Araki S, Soumura M, Sugimoto T, Isshiki K, Chin-Kanasaki M, Sakaguchi M, Koya D, Haneda M, Kashiwagi A, Uzu T. Deji N, et al. Among authors: kashiwagi a. Am J Physiol Renal Physiol. 2009 Jan;296(1):F118-26. doi: 10.1152/ajprenal.00110.2008. Epub 2008 Oct 29. Am J Physiol Renal Physiol. 2009. PMID: 18971213
We therefore investigated the structural and functional changes in the kidneys of C57BL/6 mice on a HFD. Six-week-old mice were fed a low-fat diet (LFD; 10% of total calories from fat) or a HFD (60% fat) for 12 wk. ...These systemic and renal alterations in m …
We therefore investigated the structural and functional changes in the kidneys of C57BL/6 mice on a HFD. Six-week-old mice were fed …
Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons.
Kim H, Sasaki T, Maeda K, Koya D, Kashiwagi A, Yasuda H. Kim H, et al. Among authors: kashiwagi a. Diabetes. 2003 Aug;52(8):2102-9. doi: 10.2337/diabetes.52.8.2102. Diabetes. 2003. PMID: 12882929
The decreased nociceptive threshold in diabetic rats was improved either after 4 weeks of LY treatment or with a single intradermal injection into the footpads. The treatment of LY for 6 weeks significantly decreased p-PKCbeta and ameliorated a decrease in cGMP cont …
The decreased nociceptive threshold in diabetic rats was improved either after 4 weeks of LY treatment or with a single intradermal i …
Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell.
Soumura M, Kume S, Isshiki K, Takeda N, Araki S, Tanaka Y, Sugimoto T, Chin-Kanasaki M, Nishio Y, Haneda M, Koya D, Kashiwagi A, Maegawa H, Uzu T. Soumura M, et al. Among authors: kashiwagi a. Biochem Biophys Res Commun. 2010 Nov 12;402(2):265-71. doi: 10.1016/j.bbrc.2010.10.012. Epub 2010 Oct 16. Biochem Biophys Res Commun. 2010. PMID: 20937260
In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or ω-3 polyunsaturated fatty acid, eicosapent …
In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 …
Relationship between metabolic risk factor clustering and cardiovascular mortality stratified by high blood glucose and obesity: NIPPON DATA90, 1990-2000.
Kadota A, Hozawa A, Okamura T, Kadowak T, Nakmaura K, Murakami Y, Hayakawa T, Kita Y, Okayama A, Nakamura Y, Kashiwagi A, Ueshima H; NIPPON DATA Research Group. Kadota A, et al. Among authors: kashiwagi a. Diabetes Care. 2007 Jun;30(6):1533-8. doi: 10.2337/dc06-2074. Epub 2007 Mar 15. Diabetes Care. 2007. PMID: 17363755 Clinical Trial.
RESEARCH DESIGN AND METHODS: We followed 7,219 Japanese men and women without a history of CVD for 9.6 years. We defined high blood pressure, high blood glucose, high triglycerides, low HDL cholesterol, and obesity as metabolic factors. ...
RESEARCH DESIGN AND METHODS: We followed 7,219 Japanese men and women without a history of CVD for 9.6 years. We defined high blood p …
603 results
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