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DNA double-strand break repair pathways, chromosomal rearrangements and cancer.
Kasparek TR, Humphrey TC. Kasparek TR, et al. Semin Cell Dev Biol. 2011 Oct;22(8):886-97. doi: 10.1016/j.semcdb.2011.10.007. Epub 2011 Oct 17. Semin Cell Dev Biol. 2011. PMID: 22027614 Review.
The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.
Aronica L, Kasparek T, Ruchman D, Marquez Y, Cipak L, Cipakova I, Anrather D, Mikolaskova B, Radtke M, Sarkar S, Pai CC, Blaikley E, Walker C, Shen KF, Schroeder R, Barta A, Forsburg SL, Humphrey TC. Aronica L, et al. Nucleic Acids Res. 2016 Feb 29;44(4):1703-17. doi: 10.1093/nar/gkv1473. Epub 2015 Dec 17. Nucleic Acids Res. 2016. PMID: 26682798 Free PMC article.
The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.
Blaikley EJ, Tinline-Purvis H, Kasparek TR, Marguerat S, Sarkar S, Hulme L, Hussey S, Wee BY, Deegan RS, Walker CA, Pai CC, Bähler J, Nakagawa T, Humphrey TC. Blaikley EJ, et al. Among authors: kasparek tr. Nucleic Acids Res. 2014 May;42(9):5644-56. doi: 10.1093/nar/gku190. Epub 2014 Mar 12. Nucleic Acids Res. 2014. PMID: 24623809 Free PMC article.