Kassahun K - Search Results

1

Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates.

Kassahun K, Davis M, Hu P, Martin B, Baillie T. Kassahun K, et al. Chem Res Toxicol. 1997 Nov;10(11):1228-33. doi: 10.1021/tx970080t. Chem Res Toxicol. 1997. PMID: 9403174

2

Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.

Kassahun K, Skordos K, McIntosh I, Slaughter D, Doss GA, Baillie TA, Yost GS. Kassahun K, et al. Chem Res Toxicol. 2005 Sep;18(9):1427-37. doi: 10.1021/tx050092b. Chem Res Toxicol. 2005. PMID: 16167835

3

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA. Kassahun K, et al. Chem Res Toxicol. 2001 Jan;14(1):62-70. doi: 10.1021/tx000180q. Chem Res Toxicol. 2001. PMID: 11170509

4

Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes.

Kassahun K, Hu P, Grillo MP, Davis MR, Jin L, Baillie TA. Kassahun K, et al. Chem Biol Interact. 1994 Mar;90(3):253-75. doi: 10.1016/0009-2797(94)90014-0. Chem Biol Interact. 1994. PMID: 8168173

5

Cytochrome P-450-mediated dehydrogenation of 2-n-propyl-2(E)-pentenoic acid, a pharmacologically-active metabolite of valproic acid, in rat liver microsomal preparations.

Kassahun K, Baillie TA. Kassahun K, et al. Drug Metab Dispos. 1993 Mar-Apr;21(2):242-8. Drug Metab Dispos. 1993. PMID: 8097692

6

In vivo formation of the thiol conjugates of reactive metabolites of 4-ene VPA and its analog 4-pentenoic acid.

Kassahun K, Abbott F. Kassahun K, et al. Drug Metab Dispos. 1993 Nov-Dec;21(6):1098-106. Drug Metab Dispos. 1993. PMID: 7905390

7

Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro.

Davis MR, Kassahun K, Jochheim CM, Brandt KM, Baillie TA. Davis MR, et al. Among authors: kassahun k. Chem Res Toxicol. 1993 May-Jun;6(3):376-83. doi: 10.1021/tx00033a020. Chem Res Toxicol. 1993. PMID: 8318660

8

Effect of carbamate thioester derivatives of methyl- and 2-chloroethyl isocyanate on glutathione levels and glutathione reductase activity in isolated rat hepatocytes.

Kassahun K, Jochheim CM, Baillie TA. Kassahun K, et al. Biochem Pharmacol. 1994 Aug 3;48(3):587-94. doi: 10.1016/0006-2952(94)90290-9. Biochem Pharmacol. 1994. PMID: 8068046

9

Reversibility in glutathione-conjugate formation.

Baillie TA, Kassahun K. Baillie TA, et al. Among authors: kassahun k. Adv Pharmacol. 1994;27:163-81. doi: 10.1016/s1054-3589(08)61032-7. Adv Pharmacol. 1994. PMID: 8068552 Review. No abstract available.

10

Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.

Kassahun K, Farrell K, Abbott F. Kassahun K, et al. Drug Metab Dispos. 1991 Mar-Apr;19(2):525-35. Drug Metab Dispos. 1991. PMID: 1676665

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