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A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis.
Okvist M, Sasso S, Roderer K, Kast P, Krengel U. Okvist M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt 10):1048-52. doi: 10.1107/S1744309109035878. Epub 2009 Sep 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 19851019 Free PMC article.
Structural and functional investigation of a secreted chorismate mutase from the plant-parasitic nematode Heterodera schachtii in the context of related enzymes from diverse origins.
Vanholme B, Kast P, Haegeman A, Jacob J, Grunewald W, Gheysen G. Vanholme B, et al. Mol Plant Pathol. 2009 Mar;10(2):189-200. doi: 10.1111/j.1364-3703.2008.00521.x. Mol Plant Pathol. 2009. PMID: 19236568 Free PMC article.
Preliminary X-ray crystallographic analysis of the secreted chorismate mutase from Mycobacterium tuberculosis: a tricky crystallization problem solved.
Krengel U, Dey R, Sasso S, Okvist M, Ramakrishnan C, Kast P. Krengel U, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt 5):441-5. doi: 10.1107/S1744309106012036. Epub 2006 Apr 12. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16682771 Free PMC article.
Exhaustive mutagenesis of six secondary active-site residues in Escherichia coli chorismate mutase shows the importance of hydrophobic side chains and a helix N-capping position for stability and catalysis.
Lassila JK, Keeffe JR, Kast P, Mayo SL. Lassila JK, et al. Biochemistry. 2007 Jun 12;46(23):6883-91. doi: 10.1021/bi700215x. Epub 2007 May 17. Biochemistry. 2007. PMID: 17506527
When inhibitors do not inhibit: critical evaluation of rational drug design targeting chorismate mutase from Mycobacterium tuberculosis.
Munack S, Leroux V, Roderer K, Ökvist M, van Eerde A, Gundersen LL, Krengel U, Kast P. Munack S, et al. Chem Biodivers. 2012 Nov;9(11):2507-27. doi: 10.1002/cbdv.201200322. Chem Biodivers. 2012. PMID: 23161632
Directed evolution of a model primordial enzyme provides insights into the development of the genetic code.
Müller MM, Allison JR, Hongdilokkul N, Gaillon L, Kast P, van Gunsteren WF, Marlière P, Hilvert D. Müller MM, et al. PLoS Genet. 2013;9(1):e1003187. doi: 10.1371/journal.pgen.1003187. Epub 2013 Jan 3. PLoS Genet. 2013. PMID: 23300488 Free PMC article.
Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner.
Sasso S, Okvist M, Roderer K, Gamper M, Codoni G, Krengel U, Kast P. Sasso S, et al. EMBO J. 2009 Jul 22;28(14):2128-42. doi: 10.1038/emboj.2009.165. Epub 2009 Jun 25. EMBO J. 2009. PMID: 19556970 Free PMC article.
Inter-Enzyme Allosteric Regulation of Chorismate Mutase in Corynebacterium glutamicum: Structural Basis of Feedback Activation by Trp.
Burschowsky D, Thorbjørnsrud HV, Heim JB, Fahrig-Kamarauskaitė JR, Würth-Roderer K, Kast P, Krengel U. Burschowsky D, et al. Among authors: kast p. Biochemistry. 2018 Feb 6;57(5):557-573. doi: 10.1021/acs.biochem.7b01018. Epub 2017 Dec 21. Biochemistry. 2018. PMID: 29178787
Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.
Burschowsky D, van Eerde A, Ökvist M, Kienhöfer A, Kast P, Hilvert D, Krengel U. Burschowsky D, et al. Among authors: kast p. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17516-21. doi: 10.1073/pnas.1408512111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422475 Free PMC article.
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