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Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health.
Fontana L, Cummings NE, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, Cava E, Spelta F, Tosti V, Syed FA, Baar EL, Veronese N, Cottrell SE, Fenske RJ, Bertozzi B, Brar HK, Pietka T, Bullock AD, Figenshau RS, Andriole GL, Merrins MJ, Alexander CM, Kimple ME, Lamming DW. Fontana L, et al. Among authors: kasza i. Cell Rep. 2016 Jul 12;16(2):520-530. doi: 10.1016/j.celrep.2016.05.092. Epub 2016 Jun 23. Cell Rep. 2016. PMID: 27346343 Free PMC article. Clinical Trial.
Syndecan-1 is required to maintain intradermal fat and prevent cold stress.
Kasza I, Suh Y, Wollny D, Clark RJ, Roopra A, Colman RJ, MacDougald OA, Shedd TA, Nelson DW, Yen MI, Yen CL, Alexander CM. Kasza I, et al. PLoS Genet. 2014 Aug 7;10(8):e1004514. doi: 10.1371/journal.pgen.1004514. eCollection 2014 Aug. PLoS Genet. 2014. PMID: 25101993 Free PMC article.
Dermal white adipose tissue: a new component of the thermogenic response.
Alexander CM, Kasza I, Yen CL, Reeder SB, Hernando D, Gallo RL, Jahoda CA, Horsley V, MacDougald OA. Alexander CM, et al. Among authors: kasza i. J Lipid Res. 2015 Nov;56(11):2061-9. doi: 10.1194/jlr.R062893. Epub 2015 Sep 24. J Lipid Res. 2015. PMID: 26405076 Free PMC article. Review.
Restoration of metabolic health by decreased consumption of branched-chain amino acids.
Cummings NE, Williams EM, Kasza I, Konon EN, Schaid MD, Schmidt BA, Poudel C, Sherman DS, Yu D, Arriola Apelo SI, Cottrell SE, Geiger G, Barnes ME, Wisinski JA, Fenske RJ, Matkowskyj KA, Kimple ME, Alexander CM, Merrins MJ, Lamming DW. Cummings NE, et al. Among authors: kasza i. J Physiol. 2018 Feb 15;596(4):623-645. doi: 10.1113/JP275075. Epub 2017 Dec 27. J Physiol. 2018. PMID: 29266268 Free PMC article.
Evaporative cooling provides a major metabolic energy sink.
Kasza I, Adler D, Nelson DW, Eric Yen CL, Dumas S, Ntambi JM, MacDougald OA, Hernando D, Porter WP, Best FA, Alexander CM. Kasza I, et al. Mol Metab. 2019 Sep;27:47-61. doi: 10.1016/j.molmet.2019.06.023. Epub 2019 Jul 1. Mol Metab. 2019. PMID: 31302039 Free PMC article.
Alternative Splicing and Cleavage of GLUT8.
Alexander CM, Martin JA, Oxman E, Kasza I, Senn KA, Dvinge H. Alexander CM, et al. Among authors: kasza i. Mol Cell Biol. 2020 Dec 21;41(1):e00480-20. doi: 10.1128/MCB.00480-20. Print 2020 Dec 21. Mol Cell Biol. 2020. PMID: 33077497 Free PMC article.
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.
Yu D, Richardson NE, Green CL, Spicer AB, Murphy ME, Flores V, Jang C, Kasza I, Nikodemova M, Wakai MH, Tomasiewicz JL, Yang SE, Miller BR, Pak HH, Brinkman JA, Rojas JM, Quinn WJ 3rd, Cheng EP, Konon EN, Haider LR, Finke M, Sonsalla M, Alexander CM, Rabinowitz JD, Baur JA, Malecki KC, Lamming DW. Yu D, et al. Among authors: kasza i. Cell Metab. 2021 May 4;33(5):905-922.e6. doi: 10.1016/j.cmet.2021.03.025. Epub 2021 Apr 21. Cell Metab. 2021. PMID: 33887198 Free PMC article.
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