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Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.
Toyama K, Yonezawa A, Tsuda M, Masuda S, Yano I, Terada T, Osawa R, Katsura T, Hosokawa M, Fujimoto S, Inagaki N, Inui K. Toyama K, et al. Among authors: Katsura T. Pharmacogenet Genomics. 2010 Feb;20(2):135-8. doi: 10.1097/FPC.0b013e328335639f. Pharmacogenet Genomics. 2010. PMID: 20016398 Clinical Trial.
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