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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 2
2000 2
2002 1
2003 1
2004 5
2005 4
2006 5
2007 4
2008 2
2009 5
2010 7
2011 9
2012 7
2013 6
2014 11
2015 8
2016 9
2017 11
2018 8
2019 7
2020 6
2021 6
2022 5
2023 4
2024 2

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125 results

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Page 1
Excess BAFF May Impact HIV-1-Specific Antibodies and May Promote Polyclonal Responses Including Those from First-Line Marginal Zone B-Cell Populations.
Doyon-Laliberté K, Aranguren M, Chagnon-Choquet J, Batraville LA, Dagher O, Richard J, Paniconi M, Routy JP, Tremblay C, Quintal MC, Brassard N, Kaufmann DE, Finzi A, Poudrier J, Roger M. Doyon-Laliberté K, et al. Among authors: kaufmann de. Curr Issues Mol Biol. 2023 Dec 19;46(1):25-43. doi: 10.3390/cimb46010003. Curr Issues Mol Biol. 2023. PMID: 38275663 Free PMC article.
In HIV-uninfected individuals, MZp present a B-cell regulatory (Breg) profile and function, which are lost in classic-progressors. ...RNASeq analyses reveal that blood MZp from classic-progressors are prone to Ig production and preferentially make usage of IGHV genes assoc …
In HIV-uninfected individuals, MZp present a B-cell regulatory (Breg) profile and function, which are lost in classic-progressors. .. …
Enhanced detection of antigen-specific T cells by a multiplexed AIM assay.
Lemieux A, Sannier G, Nicolas A, Nayrac M, Delgado GG, Cloutier R, Brassard N, Laporte M, Duchesne M, Sreng Flores AM, Finzi A, Tastet O, Dubé M, Kaufmann DE. Lemieux A, et al. Among authors: kaufmann de. Cell Rep Methods. 2024 Jan 22;4(1):100690. doi: 10.1016/j.crmeth.2023.100690. Epub 2024 Jan 15. Cell Rep Methods. 2024. PMID: 38228152 Free PMC article.
Supervised and unsupervised clustering analyses show differential expression of the AIMs in defined T helper lineages and that multiplexing mitigates phenotypic biases. Paired and unpaired comparisons of responses to infections (HIV and cytomegalovirus [CMV]) and vaccinati …
Supervised and unsupervised clustering analyses show differential expression of the AIMs in defined T helper lineages and that multiplexing …
Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.
Benlarbi M, Richard J, Bourassa C, Tolbert WD, Chartrand-Lefebvre C, Gendron-Lepage G, Sylla M, El-Far M, Messier-Peet M, Guertin C, Turcotte I, Fromentin R, Verly MM, Prévost J, Clark A, Mothes W, Kaufmann DE, Maldarelli F, Chomont N, Bégin P, Tremblay C, Baril JG, Trottier B, Trottier S, Duerr R, Pazgier M, Durand M, Finzi A. Benlarbi M, et al. Among authors: kaufmann de. J Infect Dis. 2024 Mar 14;229(3):763-774. doi: 10.1093/infdis/jiad503. J Infect Dis. 2024. PMID: 38035854 Free PMC article.
BACKGROUND: Chronic inflammation persists in some people living with human immunodeficiency virus (HIV) during antiretroviral therapy and is associated with premature aging. The glycoprotein 120 (gp120) subunit of HIV-1 envelope sheds and can be detected in plasma, …
BACKGROUND: Chronic inflammation persists in some people living with human immunodeficiency virus (HIV) during antiretroviral therapy …
Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4(+) and CD8(+) T cells.
Dubé M, Tastet O, Dufour C, Sannier G, Brassard N, Delgado GG, Pagliuzza A, Richard C, Nayrac M, Routy JP, Prat A, Estes JD, Fromentin R, Chomont N, Kaufmann DE. Dubé M, et al. Among authors: kaufmann de. Cell Host Microbe. 2023 Sep 13;31(9):1507-1522.e5. doi: 10.1016/j.chom.2023.08.006. Cell Host Microbe. 2023. PMID: 37708853 Free article.
Using multiplexed single-cell RNAflow-fluorescence in situ hybridization (FISH), we detect active HIV transcription in 14/18 people with HIV on suppressive ART, with a median of 28/million CD4(+) T cells. ...The magnitude of the active reservoir positively correlate …
Using multiplexed single-cell RNAflow-fluorescence in situ hybridization (FISH), we detect active HIV transcription in 14/18 people w …
Plasmatic HIV-1 soluble gp120 is associated with immune dysfunction and inflammation in ART-treated individuals with undetectable viremia.
Benlarbi M, Richard J, Bourassa C, Tolbert WD, Chartrand-Lefebvre C, Gendron-Lepage G, Sylla M, El-Far M, Messier-Peet M, Guertin C, Turcotte I, Fromentin R, Verly MM, Prévost J, Clark A, Mothes W, Kaufmann DE, Maldarelli F, Chomont N, Bégin P, Tremblay C, Baril JG, Trottier B, Trottier S, Duerr R, Pazgier M, Durand M, Finzi A; Canadian HIV; Aging Cohort Study. Benlarbi M, et al. Among authors: kaufmann de. medRxiv [Preprint]. 2023 Aug 16:2023.08.15.23294128. doi: 10.1101/2023.08.15.23294128. medRxiv. 2023. Update in: J Infect Dis. 2024 Mar 14;229(3):763-774. doi: 10.1093/infdis/jiad503. PMID: 37645879 Free PMC article. Updated. Preprint.
BACKGROUND: Chronic inflammation persists in some people living with HIV (PLWH), even during antiretroviral therapy (ART) and is associated with premature aging. The gp120 subunit of the HIV-1 envelope glycoprotein can shed from viral and cellular membranes and can …
BACKGROUND: Chronic inflammation persists in some people living with HIV (PLWH), even during antiretroviral therapy (ART) and is asso …
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.
Richard J, Prévost J, Bourassa C, Brassard N, Boutin M, Benlarbi M, Goyette G, Medjahed H, Gendron-Lepage G, Gaudette F, Chen HC, Tolbert WD, Smith AB 3rd, Pazgier M, Dubé M, Clark A, Mothes W, Kaufmann DE, Finzi A. Richard J, et al. Among authors: kaufmann de. Cell Chem Biol. 2023 May 18;30(5):540-552.e6. doi: 10.1016/j.chembiol.2023.03.003. Epub 2023 Mar 22. Cell Chem Biol. 2023. PMID: 36958337 Free PMC article.
While HIV-1-mediated CD4 downregulation protects infected cells from antibody-dependent cellular cytotoxicity (ADCC), shed gp120 binds to CD4 on uninfected bystander CD4(+) T cells, sensitizing them to ADCC mediated by HIV(+) plasma. Soluble gp120-CD4 interaction on …
While HIV-1-mediated CD4 downregulation protects infected cells from antibody-dependent cellular cytotoxicity (ADCC), shed gp120 bind …
Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-Cells in the Context of HIV-1 Infection.
Doyon-Laliberté K, Aranguren M, Byrns M, Chagnon-Choquet J, Paniconi M, Routy JP, Tremblay C, Quintal MC, Brassard N, Kaufmann DE, Poudrier J, Roger M. Doyon-Laliberté K, et al. Among authors: kaufmann de. Int J Mol Sci. 2022 Dec 1;23(23):15142. doi: 10.3390/ijms232315142. Int J Mol Sci. 2022. PMID: 36499469 Free PMC article.
Furthermore, we have shown MZp regulatory function to involve CD83 signaling. To address the impact of HIV infection and excessive BAFF on MZp Breg capacities, we have performed transcriptomic analyses by RNA-seq of sorted MZp B-cells from the blood of HIV-infected …
Furthermore, we have shown MZp regulatory function to involve CD83 signaling. To address the impact of HIV infection and excessive BA …
Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function.
Brunet-Ratnasingham E, Morou A, Dubé M, Niessl J, Baxter AE, Tastet O, Brassard N, Ortega-Delgado G, Charlebois R, Freeman GJ, Tremblay C, Routy JP, Kaufmann DE. Brunet-Ratnasingham E, et al. Among authors: kaufmann de, baxter ae. EBioMedicine. 2022 Oct;84:104254. doi: 10.1016/j.ebiom.2022.104254. Epub 2022 Sep 20. EBioMedicine. 2022. PMID: 36150362 Free PMC article.
METHODS: We examined immune checkpoint (IC) expression and function in HIV-specific CD4+ T cells of viremic individuals (5000 vRNA cp/ml, n = 17) prior to ART and persons with spontaneous (n = 11) or therapy-induced (n = 16) viral suppression (<40 cp/ml). ...This hetero …
METHODS: We examined immune checkpoint (IC) expression and function in HIV-specific CD4+ T cells of viremic individuals (5000 vRNA cp …
Detecting Sources of Immune Activation and Viral Rebound in HIV Infection.
Wietgrefe SW, Duan L, Anderson J, Marqués G, Sanders M, Cummins NW, Badley AD, Dobrowolski C, Karn J, Pagliuzza A, Chomont N, Sannier G, Dubé M, Kaufmann DE, Zuck P, Wu G, Howell BJ, Reilly C, Herschhorn A, Schacker TW, Haase AT. Wietgrefe SW, et al. Among authors: kaufmann de. J Virol. 2022 Aug 10;96(15):e0088522. doi: 10.1128/jvi.00885-22. Epub 2022 Jul 20. J Virol. 2022. PMID: 35856674 Free PMC article.
We report a comparison of assays of two potential sources of immune activation during ART: rare cells producing HIV and the virus' major viral protein, p24, benchmarked on a cell model of active and latent infections and a method to visualize HIV-producing cells. We …
We report a comparison of assays of two potential sources of immune activation during ART: rare cells producing HIV and the virus' ma …
Covid-19 vaccine immunogenicity in people living with HIV-1.
Nault L, Marchitto L, Goyette G, Tremblay-Sher D, Fortin C, Martel-Laferrière V, Trottier B, Richard J, Durand M, Kaufmann D, Finzi A, Tremblay C. Nault L, et al. Among authors: kaufmann d. Vaccine. 2022 Jun 9;40(26):3633-3637. doi: 10.1016/j.vaccine.2022.04.090. Epub 2022 May 5. Vaccine. 2022. PMID: 35568588 Free PMC article.
We evaluated immunogenicity of an mRNA anti-SARS CoV-2 vaccine in HIV-positive individuals. METHODS: HIV-positive individuals (n = 121) were recruited from HIV clinics in Montreal and stratified according to their CD4 counts. ...However, HIV-positive i …
We evaluated immunogenicity of an mRNA anti-SARS CoV-2 vaccine in HIV-positive individuals. METHODS: HIV-positive individuals …
125 results