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Page 1
An engineered protein antagonist of K-Ras/B-Raf interaction.
Kauke MJ, Traxlmayr MW, Parker JA, Kiefer JD, Knihtila R, McGee J, Verdine G, Mattos C, Wittrup KD. Kauke MJ, et al. Sci Rep. 2017 Jul 19;7(1):5831. doi: 10.1038/s41598-017-05889-7. Sci Rep. 2017. PMID: 28724936 Free PMC article.
Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins.
Yang NJ, Kauke MJ, Sun F, Yang LF, Maass KF, Traxlmayr MW, Yu Y, Xu Y, Langer RS, Anderson DG, Wittrup KD. Yang NJ, et al. Among authors: kauke mj. Nucleic Acids Res. 2017 Jul 27;45(13):7602-7614. doi: 10.1093/nar/gkx546. Nucleic Acids Res. 2017. PMID: 28641400 Free PMC article.
Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.
Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, Wittrup KD. Zhu EF, et al. Among authors: kauke mj. Cancer Cell. 2015 Apr 13;27(4):489-501. doi: 10.1016/j.ccell.2015.03.004. Cancer Cell. 2015. PMID: 25873172 Free PMC article.
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.
Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kumari S, Kelly RL, Kwan BH, Abraham W, Hu K, Mehta NK, Kauke MJ, Suh H, Cochran JR, Lauffenburger DA, Wittrup KD, Irvine DJ. Moynihan KD, et al. Among authors: kauke mj. Nat Med. 2016 Dec;22(12):1402-1410. doi: 10.1038/nm.4200. Epub 2016 Oct 24. Nat Med. 2016. PMID: 27775706 Free PMC article.
Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses.
Kwan BH, Zhu EF, Tzeng A, Sugito HR, Eltahir AA, Ma B, Delaney MK, Murphy PA, Kauke MJ, Angelini A, Momin N, Mehta NK, Maragh AM, Hynes RO, Dranoff G, Cochran JR, Wittrup KD. Kwan BH, et al. Among authors: kauke mj. J Exp Med. 2017 Jun 5;214(6):1679-1690. doi: 10.1084/jem.20160831. Epub 2017 May 4. J Exp Med. 2017. PMID: 28473400 Free PMC article.
Durable antitumor responses to CD47 blockade require adaptive immune stimulation.
Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC. Sockolosky JT, et al. Among authors: kauke mj. Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2646-54. doi: 10.1073/pnas.1604268113. Epub 2016 Apr 18. Proc Natl Acad Sci U S A. 2016. PMID: 27091975 Free PMC article.