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The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.
Manfroni G, Cannalire R, Barreca ML, Kaushik-Basu N, Leyssen P, Winquist J, Iraci N, Manvar D, Paeshuyse J, Guhamazumder R, Basu A, Sabatini S, Tabarrini O, Danielson UH, Neyts J, Cecchetti V. Manfroni G, et al. J Med Chem. 2014 Mar 13;57(5):1952-63. doi: 10.1021/jm401362f. Epub 2013 Nov 6. J Med Chem. 2014. PMID: 24131104 Free PMC article.
New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2.
Manvar D, Pelliccia S, La Regina G, Famiglini V, Coluccia A, Ruggieri A, Anticoli S, Lee JC, Basu A, Cevik O, Nencioni L, Palamara AT, Zamperini C, Botta M, Neyts J, Leyssen P, Kaushik-Basu N, Silvestri R. Manvar D, et al. Eur J Med Chem. 2015 Jan 27;90:497-506. doi: 10.1016/j.ejmech.2014.11.042. Epub 2014 Nov 27. Eur J Med Chem. 2015. PMID: 25483263 Free article.
Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold.
Andreev IA, Manvar D, Barreca ML, Belov DS, Basu A, Sweeney NL, Ratmanova NK, Lukyanenko ER, Manfroni G, Cecchetti V, Frick DN, Altieri A, Kaushik-Basu N, Kurkin AV. Andreev IA, et al. Among authors: kaushik basu n. Eur J Med Chem. 2015;96:250-8. doi: 10.1016/j.ejmech.2015.04.022. Epub 2015 Apr 10. Eur J Med Chem. 2015. PMID: 25890075 Free PMC article.
5-Carba-pterocarpens: A new scaffold with anti-HCV activity.
Fernandes TA, Manvar D, Domingos JLO, Basu A, Nichols DB, Kaushik-Basu N, Costa PRR. Fernandes TA, et al. Among authors: kaushik basu n. Eur J Med Chem. 2016 Apr 13;112:33-38. doi: 10.1016/j.ejmech.2016.02.010. Epub 2016 Feb 6. Eur J Med Chem. 2016. PMID: 26874742
40 results