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Substance P receptors and signal transduction in leukocytes.
Kavelaars A, Jeurissen F, Heijnen CJ. Kavelaars A, et al. Immunomethods. 1994 Aug;5(1):41-8. doi: 10.1006/immu.1994.1036. Immunomethods. 1994. PMID: 7531101
Apart from the receptor-independent activation pathway, Substance P can also activate monocytes and B cells via a nonneurokinin Substance P receptor. ...
Apart from the receptor-independent activation pathway, Substance P can also activate monocytes and B cells via a nonneurokinin Subst …
Expression of preproenkephalin mRNA and production and secretion of enkephalins by human thymocytes.
Kavelaars A, Heijnen CJ. Kavelaars A, et al. Ann N Y Acad Sci. 2000;917:778-83. doi: 10.1111/j.1749-6632.2000.tb05443.x. Ann N Y Acad Sci. 2000. PMID: 11268407
Moreover, a culture of thymocytes with the cytokines results in intracellular expression of MENK as determined by immunohistochemistry. ...
Moreover, a culture of thymocytes with the cytokines results in intracellular expression of MENK as determined by immunohistochemistr …
Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome.
Kavelaars A, Kuis W, Knook L, Sinnema G, Heijnen CJ. Kavelaars A, et al. J Clin Endocrinol Metab. 2000 Feb;85(2):692-6. doi: 10.1210/jcem.85.2.6379. J Clin Endocrinol Metab. 2000. PMID: 10690878
We conclude that CFS is accompanied by a relative resistance of the immune system to regulation by the neuroendocrine system. Based on these data, we suggest CFS should be viewed as a disease of deficient neuroendocrine-immune communication....
We conclude that CFS is accompanied by a relative resistance of the immune system to regulation by the neuroendocrine system. Based o …
The importance of being receptive.
Heijnen CJ, Kavelaars A. Heijnen CJ, et al. Among authors: kavelaars a. J Neuroimmunol. 1999 Dec;100(1-2):197-202. doi: 10.1016/s0165-5728(99)00194-0. J Neuroimmunol. 1999. PMID: 10695730 Review.
Role of endogenous pro-enkephalin A-derived peptides in human T cell proliferation and monocyte IL-6 production.
Kamphuis S, Eriksson F, Kavelaars A, Zijlstra J, van de Pol M, Kuis W, Heijnen CJ. Kamphuis S, et al. Among authors: kavelaars a. J Neuroimmunol. 1998 Apr 1;84(1):53-60. doi: 10.1016/s0165-5728(97)00240-3. J Neuroimmunol. 1998. PMID: 9600708
In this paper, we describe that met-enkephalin and/or enkephalin-containing intermediary peptides of the prohormone pro-enkephalin A are produced and secreted by human peripheral blood T cells and monocytes. ...
In this paper, we describe that met-enkephalin and/or enkephalin-containing intermediary peptides of the prohormone pro-enkephalin A
Ontogency of the responses of human peripheral blood T cells to glucocorticoids.
Kavelaars A, Cats B, Visser GH, Zegers BJ, Bakker JM, van Rees EP, Heunen CJ. Kavelaars A, et al. Brain Behav Immun. 1996 Sep;10(3):288-97. doi: 10.1006/brbi.1996.0025. Brain Behav Immun. 1996. PMID: 8954600 Clinical Trial.
Modulation of the immune response by proopiomelanocortin derived peptides. II. Influence of adrenocorticotropic hormone on the rise in intracellular free calcium concentration after T cell activation.
Kavelaars A, Ballieux RE, Heijnen C. Kavelaars A, et al. Brain Behav Immun. 1988 Mar;2(1):57-66. doi: 10.1016/0889-1591(88)90006-2. Brain Behav Immun. 1988. PMID: 3263158
The increase in cytosolic free calcium induced by concanavalin A or by a monoclonal antibody with specificity for the T cell receptor-T3 complex could be modulated by physiological concentrations of ACTH 1-24. ...
The increase in cytosolic free calcium induced by concanavalin A or by a monoclonal antibody with specificity for the T cell r …
Monocytes express a non-neurokinin substance P receptor that is functionally coupled to MAP kinase.
Jeurissen F, Kavelaars A, Korstjens M, Broeke D, Franklin RA, Gelfand EW, Heijnen CJ. Jeurissen F, et al. Among authors: kavelaars a. J Immunol. 1994 Mar 15;152(6):2987-94. J Immunol. 1994. PMID: 7511635
Cross-linking studies with disuccinimidylsuberate, followed by SDS-PAGE analysis, revealed that 125I-BH-SP is specifically bound to a membrane protein with an apparent molecular mass of 47 kDa. ...From these results, we conclude that this SP binding site on monocytes is …
Cross-linking studies with disuccinimidylsuberate, followed by SDS-PAGE analysis, revealed that 125I-BH-SP is specifically bound to a
Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis.
Lombardi MS, Kavelaars A, Schedlowski M, Bijlsma JW, Okihara KL, Van de Pol M, Ochsmann S, Pawlak C, Schmidt RE, Heijnen CJ. Lombardi MS, et al. Among authors: kavelaars a. FASEB J. 1999 Apr;13(6):715-25. doi: 10.1096/fasebj.13.6.715. FASEB J. 1999. PMID: 10094932
We found a significant decrease in GRK activity in RA subjects that is mirrored by a decrease in GRK-2 protein expression. Moreover, GRK-6 protein expression is reduced in RA patients whereas GRK-5 protein levels were unchanged. In search of an underlying mechanism, …
We found a significant decrease in GRK activity in RA subjects that is mirrored by a decrease in GRK-2 protein expression. Mor …
Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes.
Rouppe van der Voort C, Kavelaars A, van de Pol M, Heijnen CJ. Rouppe van der Voort C, et al. Among authors: kavelaars a. J Neuroimmunol. 1999 Mar 1;95(1-2):165-73. doi: 10.1016/s0165-5728(99)00011-9. J Neuroimmunol. 1999. PMID: 10229127
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