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New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep
Bannai M and Kawai N. J Pharmacol Sci 2012 - Review. PMID 22293292
Glycine is a non-essential amino acid that has indispensable roles in both excitatory and inhibitory neurotransmission via N-methyl-D-aspartate type glutamate receptors and glycine receptors, respectively. ...
Glycine is a non-essential amino acid that has indispensable roles in both excitatory and inhibitory neurotransmission via N-methyl-D …
The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus
Kawai N, et al. Neuropsychopharmacology 2015. PMID 25533534 Free PMC article.
Pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists AP5 and CGP78608 but not the glycine receptor antagonist strychnine inhibited the CBF increase caused by glycine injection into the brain. ...
Pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists AP5 and CGP78608 but not the glycine receptor antagonist strychnin …
Pharmacokinetics and cerebral distribution of glycine administered to rats
Kawai N, et al. Amino Acids 2012. PMID 21647662
High doses of glycine have been reported to improve negative schizophrenic symptoms, suggesting that ingested glycine activates glutamatergic transmission via N-methyl-D-aspartate (NMDA) receptors. ...
High doses of glycine have been reported to improve negative schizophrenic symptoms, suggesting that ingested glycine activates glutamatergi …
Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats
Bannai M, et al. Psychiatry Clin Neurosci 2011. Among authors: Kawai N. PMID 21414089
CONCLUSIONS: It is possible that the increase in 5-HT in response to glycine and d-serine was mediated by N-methyl-D-aspartate receptors. ...
CONCLUSIONS: It is possible that the increase in 5-HT in response to glycine and d-serine was mediated by N-methyl-D-aspartate recept …
Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin (mTOR) pathway
Iida K, et al. Cancer Sci 2020. Among authors: Kawai N. PMID 31994822 Free article.
Moreover, in another in vivo N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced rat bladder cancer model, the oral administration of luteolin led to a trend in decreased bladder tumor dimension and significantly decreased the Ki67-labeling index and p-S6 expression. ...
Moreover, in another in vivo N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced rat bladder cancer model, the oral administr …
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