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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K, Akira S. Adachi O, et al. Immunity. 1998 Jul;9(1):143-50. doi: 10.1016/s1074-7613(00)80596-8. Immunity. 1998. PMID: 9697844
Mice generated by gene targeting to lack MyD88 have defects in T cell proliferation as well as induction of acute phase proteins and cytokines in response to IL-1. ...
Mice generated by gene targeting to lack MyD88 have defects in T cell proliferation as well as induction of acute phase proteins and …
TLR signaling.
Kawai T, Akira S. Kawai T, et al. Cell Death Differ. 2006 May;13(5):816-25. doi: 10.1038/sj.cdd.4401850. Cell Death Differ. 2006. PMID: 16410796 Review.
IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation.
Li HM, Fujikura D, Harada T, Uehara J, Kawai T, Akira S, Reed JC, Iwai A, Miyazaki T. Li HM, et al. Cell Death Differ. 2009 Dec;16(12):1615-21. doi: 10.1038/cdd.2009.97. Epub 2009 Jul 31. Cell Death Differ. 2009. PMID: 19644511
IkappaB kinase alpha is essential for mature B cell development and function.
Kaisho T, Takeda K, Tsujimura T, Kawai T, Nomura F, Terada N, Akira S. Kaisho T, et al. J Exp Med. 2001 Feb 19;193(4):417-26. doi: 10.1084/jem.193.4.417. J Exp Med. 2001. PMID: 11181694 Free PMC article.
A Toll-like receptor recognizes bacterial DNA.
Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. Hemmi H, et al. Nature. 2000 Dec 7;408(6813):740-5. doi: 10.1038/35047123. Nature. 2000. PMID: 11130078
CpG DNA induces a strong T-helper-1-like inflammatory response. Accumulating evidence has revealed the therapeutic potential of CpG DNA as adjuvants for vaccination strategies for cancer, allergy and infectious diseases. ...The in vivo CpG-DNA-mediated T-helper type …
CpG DNA induces a strong T-helper-1-like inflammatory response. Accumulating evidence has revealed the therapeutic potential of CpG D …
NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation.
Nomura F, Kawai T, Nakanishi K, Akira S. Nomura F, et al. Genes Cells. 2000 Mar;5(3):191-202. doi: 10.1046/j.1365-2443.2000.00315.x. Genes Cells. 2000. PMID: 10759890
Unresponsiveness of MyD88-deficient mice to endotoxin.
Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. Kawai T, et al. Immunity. 1999 Jul;11(1):115-22. doi: 10.1016/s1074-7613(00)80086-2. Immunity. 1999. PMID: 10435584
Cloning of the gene encoding the Actinobacillus actinomycetemcomitans serotype b OmpA-like outer membrane protein.
Komatsuzawa H, Kawai T, Wilson ME, Taubman MA, Sugai M, Suginaka H. Komatsuzawa H, et al. Infect Immun. 1999 Feb;67(2):942-5. doi: 10.1128/IAI.67.2.942-945.1999. Infect Immun. 1999. PMID: 9916112 Free PMC article.
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