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Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes.
Schaefer O, Ohtsuki S, Kawakami H, Inoue T, Liehner S, Saito A, Sakamoto A, Ishiguro N, Matsumaru T, Terasaki T, Ebner T. Schaefer O, et al. Among authors: kawakami h. Drug Metab Dispos. 2012 Jan;40(1):93-103. doi: 10.1124/dmd.111.042275. Epub 2011 Oct 6. Drug Metab Dispos. 2012. PMID: 21979928
Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.
Ohtsuki S, Schaefer O, Kawakami H, Inoue T, Liehner S, Saito A, Ishiguro N, Kishimoto W, Ludwig-Schwellinger E, Ebner T, Terasaki T. Ohtsuki S, et al. Among authors: kawakami h. Drug Metab Dispos. 2012 Jan;40(1):83-92. doi: 10.1124/dmd.111.042259. Epub 2011 Oct 12. Drug Metab Dispos. 2012. PMID: 21994437
Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS.
Ohtsuki S, Kawakami H, Inoue T, Nakamura K, Tateno C, Katsukura Y, Obuchi W, Uchida Y, Kamiie J, Horie T, Terasaki T. Ohtsuki S, et al. Among authors: kawakami h. Drug Metab Dispos. 2014 Jun;42(6):1039-43. doi: 10.1124/dmd.114.057646. Epub 2014 Apr 7. Drug Metab Dispos. 2014. PMID: 24711249
Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry with nano-liquid chromatography.
Sakamoto A, Matsumaru T, Ishiguro N, Schaefer O, Ohtsuki S, Inoue T, Kawakami H, Terasaki T. Sakamoto A, et al. Among authors: kawakami h. J Pharm Sci. 2011 Sep;100(9):4037-43. doi: 10.1002/jps.22591. Epub 2011 May 4. J Pharm Sci. 2011. PMID: 21544820
Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin.
Niessen J, Jedlitschky G, Grube M, Bien S, Schwertz H, Ohtsuki S, Kawakami H, Kamiie J, Oswald S, Starke K, Strobel U, Siegmund W, Rosskopf D, Greinacher A, Terasaki T, Kroemer HK. Niessen J, et al. Among authors: kawakami h. Drug Metab Dispos. 2009 May;37(5):1129-37. doi: 10.1124/dmd.108.024570. Epub 2009 Feb 23. Drug Metab Dispos. 2009. PMID: 19237515
1,315 results