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Analysis of antitumor activity of an interleukin-13 (IL-13) receptor-targeted cytotoxin composed of IL-13 antagonist and Pseudomonas exotoxin.
Kioi M, Kawakami K, Puri RK. Kioi M, et al. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6231-8. doi: 10.1158/1078-0432.CCR-04-0700. Clin Cancer Res. 2004. PMID: 15448012
In addition, we have shown that IL-13 mutant IL-13E13K, in which glutamic acid (E) residue at position 13 of IL-13 molecule was substituted by a lysine (K), is a powerful antagonist of IL-13 and binds to IL-13 receptor with a higher affinity compared with wild-type IL-13. …
In addition, we have shown that IL-13 mutant IL-13E13K, in which glutamic acid (E) residue at position 13 of IL-13 molecule was substituted …
TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma.
Honjo Y, Bian Y, Kawakami K, Molinolo A, Longenecker G, Boppana R, Larsson J, Karlsson S, Gutkind JS, Puri RK, Kulkarni AB. Honjo Y, et al. Cell Cycle. 2007 Jun 1;6(11):1360-6. doi: 10.4161/cc.6.11.4268. Epub 2007 Jun 5. Cell Cycle. 2007. PMID: 17534148
Characterization of a novel human tumor antigen interleukin-13 receptor alpha2 chain.
Kawakami K, Terabe M, Kawakami M, Berzofsky JA, Puri RK. Kawakami K, et al. Cancer Res. 2006 Apr 15;66(8):4434-42. doi: 10.1158/0008-5472.CAN-05-1265. Cancer Res. 2006. PMID: 16618770
Cancer gene therapy utilizing interleukin-13 receptor alpha2 chain.
Kawakami K. Kawakami K. Curr Gene Ther. 2005 Apr;5(2):213-23. doi: 10.2174/1566523053544227. Curr Gene Ther. 2005. PMID: 15853729 Review.
Evidence that IL-13R alpha2 chain in human glioma cells is responsible for the antitumor activity mediated by receptor-directed cytotoxin therapy.
Kawakami K, Kioi M, Liu Q, Kawakami M, Puri RK. Kawakami K, et al. J Immunother. 2005 May-Jun;28(3):193-202. doi: 10.1097/01.cji.0000161393.04207.e1. J Immunother. 2005. PMID: 15838375
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