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A novel double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]tofogliflozin after oral administration and concomitant intravenous microdose administration of [13C]tofogliflozin in humans.
Schwab D, Portron A, Backholer Z, Lausecker B, Kawashima K. Schwab D, et al. Clin Pharmacokinet. 2013 Jun;52(6):463-73. doi: 10.1007/s40262-013-0051-z. Clin Pharmacokinet. 2013. PMID: 23494983 Clinical Trial.
In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes.
Nakagawa T, Fowler S, Takanashi K, Youdim K, Yamauchi T, Kawashima K, Sato-Nakai M, Yu L, Ishigai M. Nakagawa T, et al. Xenobiotica. 2018 Jun;48(6):546-554. doi: 10.1080/00498254.2017.1344910. Epub 2017 Jul 21. Xenobiotica. 2018. PMID: 28657423
Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects.
Morcos PN, Yu L, Bogman K, Sato M, Katsuki H, Kawashima K, Moore DJ, Whayman M, Nieforth K, Heinig K, Guerini E, Muri D, Martin-Facklam M, Phipps A. Morcos PN, et al. Xenobiotica. 2017 Mar;47(3):217-229. doi: 10.1080/00498254.2016.1179821. Epub 2016 May 16. Xenobiotica. 2017. PMID: 27180975
In vitro profiling of the metabolism and drug-drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP.
Yamane M, Kawashima K, Yamaguchi K, Nagao S, Sato M, Suzuki M, Honda K, Hagita H, Kuhlmann O, Poirier A, Fowler S, Funk C, Simon S, Aso Y, Ikeda S, Ishigai M. Yamane M, et al. Xenobiotica. 2015 Mar;45(3):230-8. doi: 10.3109/00498254.2014.976296. Epub 2014 Oct 28. Xenobiotica. 2015. PMID: 25350082
Metabolism and mass balance of SGLT2 inhibitor tofogliflozin following oral administration to humans.
Zell M, Husser C, Kuhlmann O, Schwab D, Uchimura T, Kemei T, Kawashima K, Yamane M, Pähler A. Zell M, et al. Xenobiotica. 2014 Apr;44(4):369-78. doi: 10.3109/00498254.2013.839847. Epub 2013 Sep 27. Xenobiotica. 2014. PMID: 24074237 Clinical Trial.
Metabolites of alectinib in human: their identification and pharmacological activity.
Sato-Nakai M, Kawashima K, Nakagawa T, Tachibana Y, Yoshida M, Takanashi K, Morcos PN, Binder M, Moore DJ, Yu L. Sato-Nakai M, et al. Heliyon. 2017 Jul 10;3(7):e00354. doi: 10.1016/j.heliyon.2017.e00354. eCollection 2017 Jul. Heliyon. 2017. PMID: 28725874 Free PMC article.
Optimal selection of endoscopic resection in patients with esophageal squamous cell carcinoma: endoscopic mucosal resection versus endoscopic submucosal dissection according to lesion size.
Kawashima K, Abe S, Koga M, Nonaka S, Suzuki H, Yoshinaga S, Oda I, Hikichi T, Ohira H, Saito Y. Kawashima K, et al. Dis Esophagus. 2020 Sep 22:doaa096. doi: 10.1093/dote/doaa096. Online ahead of print. Dis Esophagus. 2020. PMID: 32959874
Total Knee Arthroplasty with Concomitant Corrective Tibial Osteotomy Using Patient-Specific Instrumentation and Computed Tomography-Based Navigation in Severe Post-High Tibial Osteotomy Valgus Collapse.
Shibano K, Kunugiza Y, Kawashima K, Tomita T. Shibano K, et al. Among authors: kawashima k. Arthroplast Today. 2020 Aug 31;6(4):742-746. doi: 10.1016/j.artd.2020.07.029. eCollection 2020 Dec. Arthroplast Today. 2020. PMID: 32923561 Free PMC article.
Experimental and Computational Determination of Optimal Boron Content in Layered Superconductor Sc20C8-xBxC20.
Ninomiya H, Koshinuma T, Nishio T, Fujihisa H, Kawashima K, Hase I, Ishida S, Ogino H, Iyo A, Yoshida Y, Gotoh Y, Eisaki H. Ninomiya H, et al. Among authors: kawashima k. Inorg Chem. 2020 Sep 13. doi: 10.1021/acs.inorgchem.0c02090. Online ahead of print. Inorg Chem. 2020. PMID: 32921044
Simultaneous Sulfite Electrolysis and Hydrogen Production Using Ni Foam-Based Three-Dimensional Electrodes.
Márquez-Montes RA, Kawashima K, Vo KM, Chávez-Flores D, Collins-Martínez VH, Mullins CB, Ramos-Sánchez VH. Márquez-Montes RA, et al. Among authors: kawashima k. Environ Sci Technol. 2020 Sep 22. doi: 10.1021/acs.est.0c04190. Online ahead of print. Environ Sci Technol. 2020. PMID: 32902265
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