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A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.
Kaye FJ, Kratzke RA, Gerster JL, Horowitz JM. Kaye FJ, et al. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6922-6. doi: 10.1073/pnas.87.17.6922. Proc Natl Acad Sci U S A. 1990. PMID: 2168563 Free PMC article.
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M. Paez JG, et al. Science. 2004 Jun 4;304(5676):1497-500. doi: 10.1126/science.1099314. Epub 2004 Apr 29. Science. 2004. PMID: 15118125
Protein expression and functional analysis of the FHIT gene in human tumor cells.
Otterson GA, Xiao GH, Geradts J, Jin F, Chen WD, Niklinska W, Kaye FJ, Yeung RS. Otterson GA, et al. J Natl Cancer Inst. 1998 Mar 18;90(6):426-32. doi: 10.1093/jnci/90.6.426. J Natl Cancer Inst. 1998. PMID: 9521166
Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis.
Sundaresan V, Lin VT, Liang F, Kaye FJ, Kawabata-Iwakawa R, Shiraishi K, Kohno T, Yokota J, Zhou L. Sundaresan V, et al. Cancer Genet. 2017 Oct;216-217:20-28. doi: 10.1016/j.cancergen.2017.05.003. Epub 2017 Jun 7. Cancer Genet. 2017. PMID: 29025592 Free PMC article.
Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme.
Rahman L, Voeller D, Rahman M, Lipkowitz S, Allegra C, Barrett JC, Kaye FJ, Zajac-Kaye M. Rahman L, et al. Cancer Cell. 2004 Apr;5(4):341-51. doi: 10.1016/s1535-6108(04)00080-7. Cancer Cell. 2004. PMID: 15093541
Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras.
Park Y, Kubo A, Komiya T, Coxon A, Beebe K, Neckers L, Meltzer PS, Kaye FJ. Park Y, et al. Cell Cycle. 2008 Aug;7(15):2384-91. doi: 10.4161/cc.6363. Epub 2008 May 30. Cell Cycle. 2008. PMID: 18677112 Free PMC article.
CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement.
Amelio AL, Fallahi M, Schaub FX, Zhang M, Lawani MB, Alperstein AS, Southern MR, Young BM, Wu L, Zajac-Kaye M, Kaye FJ, Cleveland JL, Conkright MD. Amelio AL, et al. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3260-8. doi: 10.1073/pnas.1319176111. Epub 2014 Jul 28. Proc Natl Acad Sci U S A. 2014. PMID: 25071166 Free PMC article.
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