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Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes.
Fambrough D, McClure K, Kazlauskas A, Lander ES. Fambrough D, et al. Cell. 1999 Jun 11;97(6):727-41. doi: 10.1016/s0092-8674(00)80785-0. Cell. 1999. PMID: 10380925
Interestingly, a mutant receptor that restores the RasGAP-binding site promotes induction of an independent group of genes, normally induced by interferons. ...
Interestingly, a mutant receptor that restores the RasGAP-binding site promotes induction of an independent group of genes, normally …
Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity.
Lee JS, Kim JH, Jang IH, Kim HS, Han JM, Kazlauskas A, Yagisawa H, Suh PG, Ryu SH. Lee JS, et al. J Cell Sci. 2005 Oct 1;118(Pt 19):4405-13. doi: 10.1242/jcs.02564. J Cell Sci. 2005. PMID: 16179605
Our results suggest that the PLD1 PX domain enables PLD1 to mediate signal transduction via ERK1/2 by providing a direct binding site for PtdIns(3,4,5)P3 and by activating PLD1....
Our results suggest that the PLD1 PX domain enables PLD1 to mediate signal transduction via ERK1/2 by providing a direct binding site …
Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
Plattner R, Koleske AJ, Kazlauskas A, Pendergast AM. Plattner R, et al. Mol Cell Biol. 2004 Mar;24(6):2573-83. doi: 10.1128/mcb.24.6.2573-2583.2004. Mol Cell Biol. 2004. PMID: 14993293 Free PMC article.
Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl. PIP2, a
Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholi …
RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology.
Lei H, Qian CX, Lei J, Haddock LJ, Mukai S, Kazlauskas A. Lei H, et al. Mol Cell Biol. 2015 May;35(10):1673-85. doi: 10.1128/MCB.01248-14. Epub 2015 Mar 2. Mol Cell Biol. 2015. PMID: 25733681 Free PMC article.
In the context of a blinding eye disease, indirect activation of PDGFRα results in persistent signaling, which suppresses the level of p53 and thereby promotes viability of cells that drive pathogenesis. ...Furthermore, preventing PDGFRβ from associating with RasGAP allowe …
In the context of a blinding eye disease, indirect activation of PDGFRα results in persistent signaling, which suppresses the level o …
Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses.
Pennock S, Kazlauskas A. Pennock S, et al. Mol Cell Biol. 2012 May;32(10):1955-66. doi: 10.1128/MCB.06668-11. Epub 2012 Mar 19. Mol Cell Biol. 2012. PMID: 22431518 Free PMC article.
We report here that vitreous contains an inhibitor of PDGF-dependent activation of PDGFRα and that a major portion of this inhibitory activity is due to vascular endothelial cell growth factor A (VEGF-A). ...These findings unveil a previously unappreci …
We report here that vitreous contains an inhibitor of PDGF-dependent activation of PDGFRα and that a major portion of this inhibitory …
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
Plattner R, Irvin BJ, Guo S, Blackburn K, Kazlauskas A, Abraham RT, York JD, Pendergast AM. Plattner R, et al. Nat Cell Biol. 2003 Apr;5(4):309-19. doi: 10.1038/ncb949. Nat Cell Biol. 2003. PMID: 12652307
The c-Abl tyrosine (Tyr) kinase is activated after platelet-derived-growth factor receptor (PDGFR) stimulation in a manner that is partially dependent on Src kinase activity. ...These findings uncover a newly discovered functional interdependence between non-recepto …
The c-Abl tyrosine (Tyr) kinase is activated after platelet-derived-growth factor receptor (PDGFR) stimulation in a manner that is pa …
Vascular endothelial growth factor acts primarily via platelet-derived growth factor receptor α to promote proliferative vitreoretinopathy.
Pennock S, Haddock LJ, Mukai S, Kazlauskas A. Pennock S, et al. Am J Pathol. 2014 Nov;184(11):3052-68. doi: 10.1016/j.ajpath.2014.07.026. Epub 2014 Sep 26. Am J Pathol. 2014. PMID: 25261788 Free PMC article.
Proliferative vitreoretinopathy (PVR) is a nonneovascular blinding disease and the leading cause for failure in surgical repair of rhegmatogenous retinal detachments. ...Thus, VEGF promotes PVR by a noncanonical ability to engage platelet-derived growth factor recep …
Proliferative vitreoretinopathy (PVR) is a nonneovascular blinding disease and the leading cause for failure in surgical repair of rh …
Vascular Endothelial Cell Growth Factor A Acts via Platelet-Derived Growth Factor Receptor α To Promote Viability of Cells Enduring Hypoxia.
Pennock S, Kim LA, Kazlauskas A. Pennock S, et al. Mol Cell Biol. 2016 Aug 26;36(18):2314-27. doi: 10.1128/MCB.01019-15. Print 2016 Sep 15. Mol Cell Biol. 2016. PMID: 27325673 Free PMC article.
Vascular endothelial cell growth factor A (VEGF) is a biologically and therapeutically important growth factor because it promotes angiogenesis in response to hypoxia, which underlies a wide variety of both physiological and pathological settings. ...We concl …
Vascular endothelial cell growth factor A (VEGF) is a biologically and therapeutically important growth factor because it prom …
A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration.
James MF, Beauchamp RL, Manchanda N, Kazlauskas A, Ramesh V. James MF, et al. J Cell Sci. 2004 Jun 15;117(Pt 14):2951-61. doi: 10.1242/jcs.01156. Epub 2004 May 25. J Cell Sci. 2004. PMID: 15161943
The Na(+)/H(+) exchanger regulatory factor, NHERF, is a multifunctional adapter protein involved in a wide range of physiological activities. ...We have stably expressed a wild-type betaPDGFR, a mutant betaPDGFR (L1106A) that is incapable of interactin …
The Na(+)/H(+) exchanger regulatory factor, NHERF, is a multifunctional adapter protein involved in a wide range of physiologi …
Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis.
Van Stry M, Kazlauskas A, Schreiber SL, Symes K. Van Stry M, et al. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8233-8. doi: 10.1073/pnas.0502885102. Epub 2005 May 26. Proc Natl Acad Sci U S A. 2005. PMID: 15919820 Free PMC article.
By using a chemical inducer of dimerization to activate chimera PDGFRalphas, we have identified a role for phospholipase Cgamma (PLCgamma) in protecting cells from death. ...Furthermore, we demonstrate that small molecule inducers of dimerization provide a po …
By using a chemical inducer of dimerization to activate chimera PDGFRalphas, we have identified a role for phospholipase Cgamm …
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