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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.
Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J. Chung J, et al. Nature. 1994 Jul 7;370(6484):71-5. doi: 10.1038/370071a0. Nature. 1994. PMID: 8015612
Activation of the 70/85K S6 kinases (pp70S6k) by serine phosphorylation results in 40S ribosomal protein S6 phosphorylation and is important for G1 cell-cycle transition in a variety of cells. ...
Activation of the 70/85K S6 kinases (pp70S6k) by serine phosphorylation results in 40S ribosomal protein S6 phosphorylation and is important …
PDGF signaling in cells and mice.
Tallquist M, Kazlauskas A. Tallquist M, et al. Cytokine Growth Factor Rev. 2004 Aug;15(4):205-13. doi: 10.1016/j.cytogfr.2004.03.003. Cytokine Growth Factor Rev. 2004. PMID: 15207812 Review.
Since its discovery over three decades ago, platelet-derived growth factor (PDGF) has been a model system for learning how growth factors regulate biological processes. ...
Since its discovery over three decades ago, platelet-derived growth factor (PDGF) has been a model system for learning how growth fac …
Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
Plattner R, Koleske AJ, Kazlauskas A, Pendergast AM. Plattner R, et al. Mol Cell Biol. 2004 Mar;24(6):2573-83. doi: 10.1128/mcb.24.6.2573-2583.2004. Mol Cell Biol. 2004. PMID: 14993293 Free PMC article.
Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl. PIP2, a
Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholi …
RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology.
Lei H, Qian CX, Lei J, Haddock LJ, Mukai S, Kazlauskas A. Lei H, et al. Mol Cell Biol. 2015 May;35(10):1673-85. doi: 10.1128/MCB.01248-14. Epub 2015 Mar 2. Mol Cell Biol. 2015. PMID: 25733681 Free PMC article.
In the context of a blinding eye disease, indirect activation of PDGFRα results in persistent signaling, which suppresses the level of p53 and thereby promotes viability of cells that drive pathogenesis. ...Furthermore, preventing PDGFRβ from associating with RasGAP allowe …
In the context of a blinding eye disease, indirect activation of PDGFRα results in persistent signaling, which suppresses the level o …
Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses.
Pennock S, Kazlauskas A. Pennock S, et al. Mol Cell Biol. 2012 May;32(10):1955-66. doi: 10.1128/MCB.06668-11. Epub 2012 Mar 19. Mol Cell Biol. 2012. PMID: 22431518 Free PMC article.
We report here that vitreous contains an inhibitor of PDGF-dependent activation of PDGFRα and that a major portion of this inhibitory activity is due to vascular endothelial cell growth factor A (VEGF-A). ...These findings unveil a previously unappreci …
We report here that vitreous contains an inhibitor of PDGF-dependent activation of PDGFRα and that a major portion of this inhibitory …
Platelet-derived growth factor receptor-mediated signal transduction from endosomes.
Wang Y, Pennock SD, Chen X, Kazlauskas A, Wang Z. Wang Y, et al. J Biol Chem. 2004 Feb 27;279(9):8038-46. doi: 10.1074/jbc.M311494200. Epub 2003 Dec 2. J Biol Chem. 2004. PMID: 14660565
We showed in this communication that we are able to establish a system that allows the specific activation of endosome-associated PDGFR without the activation of the plasma membrane-associated PDGFR and without disrupting the overall endocytosis pathway. ...
We showed in this communication that we are able to establish a system that allows the specific activation of endosome-associated PDG …
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
Plattner R, Irvin BJ, Guo S, Blackburn K, Kazlauskas A, Abraham RT, York JD, Pendergast AM. Plattner R, et al. Nat Cell Biol. 2003 Apr;5(4):309-19. doi: 10.1038/ncb949. Nat Cell Biol. 2003. PMID: 12652307
The c-Abl tyrosine (Tyr) kinase is activated after platelet-derived-growth factor receptor (PDGFR) stimulation in a manner that is partially dependent on Src kinase activity. ...These findings uncover a newly discovered functional interdependence between non-recepto …
The c-Abl tyrosine (Tyr) kinase is activated after platelet-derived-growth factor receptor (PDGFR) stimulation in a manner that is pa …
Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases.
Ma G, Duan Y, Huang X, Qian CX, Chee Y, Mukai S, Cui J, Samad A, Matsubara JA, Kazlauskas A, D'Amore PA, Gu S, Lei H. Ma G, et al. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3935-43. doi: 10.1167/iovs.16-19405. Invest Ophthalmol Vis Sci. 2016. PMID: 27472081 Free PMC article.
Moreover, the cell potential of inducing PVR was examined in a rabbit model of PVR effected by intravitreal cell injection. RESULTS: We found that vitreous enhanced expression of PI5P4Kα and -β in RPE cells and that knocking down PI5P4Kα and -β abrogated vitreous-stimulate …
Moreover, the cell potential of inducing PVR was examined in a rabbit model of PVR effected by intravitreal cell injection. RESULTS: …
Vascular endothelial growth factor acts primarily via platelet-derived growth factor receptor α to promote proliferative vitreoretinopathy.
Pennock S, Haddock LJ, Mukai S, Kazlauskas A. Pennock S, et al. Am J Pathol. 2014 Nov;184(11):3052-68. doi: 10.1016/j.ajpath.2014.07.026. Epub 2014 Sep 26. Am J Pathol. 2014. PMID: 25261788 Free PMC article.
Proliferative vitreoretinopathy (PVR) is a nonneovascular blinding disease and the leading cause for failure in surgical repair of rhegmatogenous retinal detachments. ...Thus, VEGF promotes PVR by a noncanonical ability to engage platelet-derived growth factor recep …
Proliferative vitreoretinopathy (PVR) is a nonneovascular blinding disease and the leading cause for failure in surgical repair of rh …
Is neutralizing vitreal growth factors a viable strategy to prevent proliferative vitreoretinopathy?
Pennock S, Haddock LJ, Eliott D, Mukai S, Kazlauskas A. Pennock S, et al. Prog Retin Eye Res. 2014 May;40:16-34. doi: 10.1016/j.preteyeres.2013.12.006. Epub 2014 Jan 9. Prog Retin Eye Res. 2014. PMID: 24412519 Review.
A surprise that emerged in the course of testing the 'growth factor hypothesis' of PVR was the existence of a functional relationship amongst growth factors that engage platelet-derived growth factor (PDGF) receptor α (PDGFRα), a receptor tyrosine kinase that
A surprise that emerged in the course of testing the 'growth factor hypothesis' of PVR was the existence of a functional relat
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