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1993 2
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2000 20
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2002 14
2003 12
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2006 1
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171 results

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Page 1
Differential Expression of MicroRNA MiR-145 and MiR-155 Downstream Targets in Oral Cancers Exhibiting Limited Chemotherapy Resistance.
Belnap C, Divis T, Kingsley K, Howard KM. Belnap C, et al. Int J Mol Sci. 2024 Feb 10;25(4):2167. doi: 10.3390/ijms25042167. Int J Mol Sci. 2024. PMID: 38396844 Free PMC article.
However, three miR-145 downstream targets were identified in the least chemotherapy-resistant cells, exhibiting the differential upregulation of KCNA4 and SRGAP2, as well as the downregulation of FAM135A, with this expression pattern not detected in any of the other oral c …
However, three miR-145 downstream targets were identified in the least chemotherapy-resistant cells, exhibiting the differential upregulatio …
Computational Studies Show How the H463R Mutation Turns hKv1.5 into an Inactivation State.
Rahman RA, Zaman B, Khan MR, Islam MS, Rashid MH. Rahman RA, et al. J Phys Chem B. 2024 Jan 18;128(2):429-439. doi: 10.1021/acs.jpcb.3c05634. Epub 2024 Jan 5. J Phys Chem B. 2024. PMID: 38179652
These results imply that the arginine mutation associated with the AF disease in particular modulates the inactivation process of hKv1.5. Kv1.4, encoded by the KCNA4 gene, is also present in the heart. Therefore, we considered simulation studies of the equivalent H507R mut …
These results imply that the arginine mutation associated with the AF disease in particular modulates the inactivation process of hKv1.5. Kv …
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells.
Martin HR, Lysakowski A, Eatock RA. Martin HR, et al. bioRxiv [Preprint]. 2023 Nov 21:2023.11.21.563853. doi: 10.1101/2023.11.21.563853. bioRxiv. 2023. PMID: 38045305 Free PMC article. Preprint.
The distinct properties of the three K(V)1.8-dependent conductances may reflect different mixing with other K(V)1 subunits, such as K(V)1.4 (KCNA4). In K(V)1.8-null HCs of both types, residual outwardly rectifying conductances include K(V)7 (KCNQ) channels. ...
The distinct properties of the three K(V)1.8-dependent conductances may reflect different mixing with other K(V)1 subunits, such as K(V)1.4 …
Deciphering the DNA methylome in women with PCOS diagnosed using the new international evidence-based guidelines.
Wang Y, Gao X, Yang Z, Yan X, He X, Guo T, Zhao S, Zhao H, Chen ZJ. Wang Y, et al. Hum Reprod. 2023 Nov 20;38(Supplement_2):ii69-ii79. doi: 10.1093/humrep/dead191. Hum Reprod. 2023. PMID: 37982419
Two DMRs were closely related to the PCOS susceptibility genes, potassium voltage-gated channel subfamily A member 4 (KCNA4) and farnesyl-diphosphate farnesyltransferase 1 (FDFT1). Finally, based on LASSO regression, we built a methylation marker model with high accuracy f …
Two DMRs were closely related to the PCOS susceptibility genes, potassium voltage-gated channel subfamily A member 4 (KCNA4) and farn …
Genetic Predictors of Ibrutinib-related Cardiovascular Side Effects in Patients with Chronic Lymphocytic Leukemia.
Hamadeh IS, Patel JN, Jacobs R, Zeng H, He J, Hu B, Moyo TK, Soni A, Park S, Copelan E, Avalos B, Hamilton A, Steuerwald N, Ghosh N. Hamadeh IS, et al. Clin Cancer Res. 2023 Dec 1;29(23):4941-4948. doi: 10.1158/1078-0432.CCR-23-0421. Clin Cancer Res. 2023. PMID: 37738027
DNA was isolated from buccal swabs of all 50 patients and genotyped for 40 SNPs in GATA4, SGK1, KCNQ1, KCNA4, NPPA, and SCN5A using a customized next-generation sequencing panel. ...
DNA was isolated from buccal swabs of all 50 patients and genotyped for 40 SNPs in GATA4, SGK1, KCNQ1, KCNA4, NPPA, and SCN5A using a …
Genome-Wide Analysis of Kidney Renal Cell Carcinoma: Exploring Differentially Expressed Genes for Diagnostic and Therapeutic Targets.
Mathur Y, Shafie A, Alharbi B, Ashour AA, Al-Soud WA, Alhassan HH, Alharethi SH, Anjum F. Mathur Y, et al. OMICS. 2023 Aug;27(8):393-401. doi: 10.1089/omi.2023.0056. OMICS. 2023. PMID: 37624678
The elucidated set of genes, that is, CALCA, CRH, TH, CHAT, SLC18A3, FSHB, MYH6, CAV3, KCNA4, and GBX2, were then categorized as potential candidates to be explored as KIRC biomarkers. ...
The elucidated set of genes, that is, CALCA, CRH, TH, CHAT, SLC18A3, FSHB, MYH6, CAV3, KCNA4, and GBX2, were then categorized as pote …
Identification of potential prognostic markers for lung adenocarcinoma using comprehensive analysis.
Huang L, Zhang A, Tang C, Wei J, Li M, Yuan S, Zhang H, Zhang X. Huang L, et al. Mol Med Rep. 2023 Aug;28(2):149. doi: 10.3892/mmr.2023.13036. Epub 2023 Jun 23. Mol Med Rep. 2023. PMID: 37350390 Free PMC article.
Analysis of hub modules identified five hub genes, namely ANGPTL7, SLC6A4, PTPRQ, KCNA4 and TEDC2 (also known as C16orf59). Survival analysis revealed associations between hub-gene expression profiles and patient prognosis. ...
Analysis of hub modules identified five hub genes, namely ANGPTL7, SLC6A4, PTPRQ, KCNA4 and TEDC2 (also known as C16orf59). Survival …
miR-9a-5p expression is decreased in the hippocampus of rats resistant to lamotrigine: A behavioural, molecular and bioinformatics assessment.
Chmielewska N, Wawer A, Wicik Z, Osuch B, Maciejak P, Szyndler J. Chmielewska N, et al. Neuropharmacology. 2023 Apr 1;227:109425. doi: 10.1016/j.neuropharm.2023.109425. Epub 2023 Jan 25. Neuropharmacology. 2023. PMID: 36709037
Further studies are needed to propose specific genes and miRNAs responsible for diminished responsiveness to LTG. miR-9a-5p targets, like KCNA4, KCNA2, CACNB2, SCN4B, KCNC1, should receive special attention in them....
Further studies are needed to propose specific genes and miRNAs responsible for diminished responsiveness to LTG. miR-9a-5p targets, like …
miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure.
Kang GJ, Xie A, Kim E, Dudley SC Jr. Kang GJ, et al. Heart Rhythm. 2023 May;20(5):730-736. doi: 10.1016/j.hrthm.2023.01.021. Epub 2023 Jan 21. Heart Rhythm. 2023. PMID: 36693615
KCNA4 has a miR-448 binding site. OBJECTIVE: We investigated whether miR-448 was involved in the regulation of KCNA4 messenger RNA expression in ischemia. METHODS: Quantitative real-time reverse-transcriptase polymerase chain reaction was used to investigate the exp …
KCNA4 has a miR-448 binding site. OBJECTIVE: We investigated whether miR-448 was involved in the regulation of KCNA4 messenger …
Peripheral Ion Channel Genes Screening in Painful Small Fiber Neuropathy.
Ślęczkowska M, Almomani R, Marchi M, Salvi E, de Greef BTA, Sopacua M, Hoeijmakers JGJ, Lindsey P, Waxman SG, Lauria G, Faber CG, Smeets HJM, Gerrits MM. Ślęczkowska M, et al. Int J Mol Sci. 2022 Nov 15;23(22):14095. doi: 10.3390/ijms232214095. Int J Mol Sci. 2022. PMID: 36430572 Free PMC article.
Patients with SFN (n = 414) were analyzed for ANO1, ANO3, HCN1, KCNA2, KCNA4, KCNK18, KCNN1, KCNQ3, KCNQ5, KCNS1, TRPA1, TRPM8, TRPV1, TRPV3 and TRPV4 variants by single-molecule molecular inversion probes-next-generation sequencing. ...
Patients with SFN (n = 414) were analyzed for ANO1, ANO3, HCN1, KCNA2, KCNA4, KCNK18, KCNN1, KCNQ3, KCNQ5, KCNS1, TRPA1, TRPM8, TRPV1 …
171 results