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Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells.
Zorn CN, Keck S, Hendriks RW, Leitges M, Freudenberg MA, Huber M. Zorn CN, et al. Cell Signal. 2009 Jan;21(1):79-86. doi: 10.1016/j.cellsig.2008.09.010. Epub 2008 Sep 26. Cell Signal. 2009. PMID: 18848985
Bruton's tyrosine kinase (Btk) represents an important signaling element downstream of ITAM-containing receptors, e.g. FcepsilonR1 and BCR. ...
Bruton's tyrosine kinase (Btk) represents an important signaling element downstream of ITAM-containing receptors, e.g. FcepsilonR1 an …
Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells.
Keck S, Müller I, Fejer G, Savic I, Tchaptchet S, Nielsen PJ, Galanos C, Huber M, Freudenberg MA. Keck S, et al. J Immunol. 2011 May 1;186(9):5478-88. doi: 10.4049/jimmunol.1000458. Epub 2011 Mar 25. J Immunol. 2011. PMID: 21441453 Free article.
Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel.
Schmidt M, Raghavan B, Müller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen PJ, Galanos C, Roth J, Skerra A, Martin SF, Freudenberg MA, Goebeler M. Schmidt M, et al. Nat Immunol. 2010 Sep;11(9):814-9. doi: 10.1038/ni.1919. Epub 2010 Aug 15. Nat Immunol. 2010. PMID: 20711192
CD14 is required for MyD88-independent LPS signaling.
Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B. Jiang Z, et al. Nat Immunol. 2005 Jun;6(6):565-70. doi: 10.1038/ni1207. Epub 2005 May 15. Nat Immunol. 2005. PMID: 15895089
R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells.
Huber M, Kalis C, Keck S, Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Beutler B, Galanos C, Freudenberg MA. Huber M, et al. Eur J Immunol. 2006 Mar;36(3):701-11. doi: 10.1002/eji.200535593. Eur J Immunol. 2006. PMID: 16506285
Therefore, the R-form LPS under physiological conditions recruits a larger spectrum of cells in endotoxic reactions than S-form LPS. We also show that soluble CD14 at high concentrations enables CD14-negative cells to respond to S-form LPS. The presented in vitro da …
Therefore, the R-form LPS under physiological conditions recruits a larger spectrum of cells in endotoxic reactions than S-form LPS. …
Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo.
Fejer G, Drechsel L, Liese J, Schleicher U, Ruzsics Z, Imelli N, Greber UF, Keck S, Hildenbrand B, Krug A, Bogdan C, Freudenberg MA. Fejer G, et al. PLoS Pathog. 2008 Nov;4(11):e1000208. doi: 10.1371/journal.ppat.1000208. Epub 2008 Nov 14. PLoS Pathog. 2008. PMID: 19008951 Free PMC article.
Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity.
Freudenberg MA, Tchaptchet S, Keck S, Fejer G, Huber M, Schütze N, Beutler B, Galanos C. Freudenberg MA, et al. Immunobiology. 2008;213(3-4):193-203. doi: 10.1016/j.imbio.2007.11.008. Epub 2007 Dec 27. Immunobiology. 2008. PMID: 18406367 Review.
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C. Steiner H, et al. J Biol Chem. 1999 Oct 1;274(40):28669-73. doi: 10.1074/jbc.274.40.28669. J Biol Chem. 1999. PMID: 10497236
Although Alzheimer's disease-associated mutations in the homologous presenilin (PS2) gene elevate amyloid beta-peptide (Abeta42) production like PS1 mutations, here we demonstrate that a gene ablation of PS2 (unlike that of PS1) in mice does not result in a severe phenotyp …
Although Alzheimer's disease-associated mutations in the homologous presenilin (PS2) gene elevate amyloid beta-peptide (Abeta42) prod …
Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch.
Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C. Capell A, et al. Nat Cell Biol. 2000 Apr;2(4):205-11. doi: 10.1038/35008626. Nat Cell Biol. 2000. PMID: 10783238
Mutations in the presenilin-1 (PS1) gene are associated with Alzheimer's disease and cause increased secretion of the neurotoxic amyloid-beta peptide (Abeta). ...
Mutations in the presenilin-1 (PS1) gene are associated with Alzheimer's disease and cause increased secretion of the neurotoxic amyl …
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