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Evaluation of safety and pharmacokinetics of sodium 2,2 dimethylbutyrate, a novel short chain fatty acid derivative, in a phase 1, double-blind, placebo-controlled, single-dose, and repeat-dose studies in healthy volunteers.
Perrine SP, Wargin WA, Boosalis MS, Wallis WJ, Case S, Keefer JR, Faller DV, Welch WC, Berenson RJ. Perrine SP, et al. Among authors: keefer jr. J Clin Pharmacol. 2011 Aug;51(8):1186-94. doi: 10.1177/0091270010379810. Epub 2011 Mar 21. J Clin Pharmacol. 2011. PMID: 21422239 Free PMC article. Clinical Trial.
A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease.
Kutlar A, Ataga K, Reid M, Vichinsky EP, Neumayr L, Blair-Britt L, Labotka R, Glass J, Keefer JR, Wargin WA, Berenson R, Perrine SP. Kutlar A, et al. Among authors: keefer jr. Am J Hematol. 2012 Nov;87(11):1017-21. doi: 10.1002/ajh.23306. Epub 2012 Aug 7. Am J Hematol. 2012. PMID: 22887019 Free PMC article. Clinical Trial.
Sickle cell disease (SCD), iNKT cells, and regadenoson infusion.
Nathan DG, Field J, Lin G, Neuberg D, Majerus E, Onyekwere O, Keefer J, Okam M, Ross A, Linden J. Nathan DG, et al. Trans Am Clin Climatol Assoc. 2012;123:312-7; discussion 317-8. Trans Am Clin Climatol Assoc. 2012. PMID: 23303999 Free PMC article. Clinical Trial.
Inpatient management of sickle cell pain: a 'snapshot' of current practice.
Miller ST, Kim HY, Weiner D, Wager CG, Gallagher D, Styles L, Dampier CD; Investigators of the Sickle Cell Disease Clinical Research Network (SCDCRN). Miller ST, et al. Am J Hematol. 2012 Mar;87(3):333-6. doi: 10.1002/ajh.22265. Epub 2012 Jan 9. Am J Hematol. 2012. PMID: 22231150 Free PMC article.
Opioid patient controlled analgesia use during the initial experience with the IMPROVE PCA trial: a phase III analgesic trial for hospitalized sickle cell patients with painful episodes.
Dampier CD, Smith WR, Kim HY, Wager CG, Bell MC, Minniti CP, Keefer J, Hsu L, Krishnamurti L, Mack AK, McClish D, McKinlay SM, Miller ST, Osunkwo I, Seaman P, Telen MJ, Weiner DL; Investigators of the Sickle Cell Disease Clinical Research Network (SCDCRN). Dampier CD, et al. Am J Hematol. 2011 Dec;86(12):E70-3. doi: 10.1002/ajh.22176. Epub 2011 Sep 22. Am J Hematol. 2011. PMID: 21953763 Free PMC article. Clinical Trial.
Clinical trial implementation and recruitment: lessons learned from the early closure of a randomized clinical trial.
Peters-Lawrence MH, Bell MC, Hsu LL, Osunkwo I, Seaman P, Blackwood M, Guillaume E, Bellevue R, Krishnamurti L, Smith WR, Dampier CD, Minniti CP; Sickle Cell Disease Clinical Research Network (SCDCRN). Peters-Lawrence MH, et al. Contemp Clin Trials. 2012 Mar;33(2):291-7. doi: 10.1016/j.cct.2011.11.018. Epub 2011 Dec 2. Contemp Clin Trials. 2012. PMID: 22155024 Free PMC article. Clinical Trial.
Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG).
Wang WC, Ware RE, Miller ST, Iyer RV, Casella JF, Minniti CP, Rana S, Thornburg CD, Rogers ZR, Kalpatthi RV, Barredo JC, Brown RC, Sarnaik SA, Howard TH, Wynn LW, Kutlar A, Armstrong FD, Files BA, Goldsmith JC, Waclawiw MA, Huang X, Thompson BW; BABY HUG investigators. Wang WC, et al. Lancet. 2011 May 14;377(9778):1663-72. doi: 10.1016/S0140-6736(11)60355-3. Lancet. 2011. PMID: 21571150 Free PMC article. Clinical Trial.
Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia.
Bhatnagar P, Keefer JR, Casella JF, Barron-Casella EA, Bean CJ, Hooper CW, Payne AB, Arking DE, Debaun MR. Bhatnagar P, et al. Among authors: keefer jr. Pediatr Blood Cancer. 2013 Oct;60(10):E125-7. doi: 10.1002/pbc.24588. Epub 2013 May 15. Pediatr Blood Cancer. 2013. PMID: 23677903 Free PMC article. Clinical Trial.
41 results