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AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex.
Ruzin A, Keeney D, Bradford PA. Ruzin A, et al. Among authors: keeney d. J Antimicrob Chemother. 2007 May;59(5):1001-4. doi: 10.1093/jac/dkm058. Epub 2007 Mar 15. J Antimicrob Chemother. 2007. PMID: 17363424
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.
Yang Y, Severin A, Chopra R, Krishnamurthy G, Singh G, Hu W, Keeney D, Svenson K, Petersen PJ, Labthavikul P, Shlaes DM, Rasmussen BA, Failli AA, Shumsky JS, Kutterer KM, Gilbert A, Mansour TS. Yang Y, et al. Among authors: keeney d. Antimicrob Agents Chemother. 2006 Feb;50(2):556-64. doi: 10.1128/AAC.50.2.556-564.2006. Antimicrob Agents Chemother. 2006. PMID: 16436710 Free PMC article.
Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials.
Jones CH, Tuckman M, Keeney D, Ruzin A, Bradford PA. Jones CH, et al. Among authors: keeney d. Antimicrob Agents Chemother. 2009 Feb;53(2):465-75. doi: 10.1128/AAC.00883-08. Epub 2008 Nov 17. Antimicrob Agents Chemother. 2009. PMID: 19015360 Free PMC article.
Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae.
Ruzin A, Visalli MA, Keeney D, Bradford PA. Ruzin A, et al. Among authors: keeney d. Antimicrob Agents Chemother. 2005 Mar;49(3):1017-22. doi: 10.1128/AAC.49.3.1017-1022.2005. Antimicrob Agents Chemother. 2005. PMID: 15728897 Free PMC article.
AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.
Ruzin A, Keeney D, Bradford PA. Ruzin A, et al. Among authors: keeney d. Antimicrob Agents Chemother. 2005 Feb;49(2):791-3. doi: 10.1128/AAC.49.2.791-793.2005. Antimicrob Agents Chemother. 2005. PMID: 15673770 Free PMC article.
MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli.
Keeney D, Ruzin A, McAleese F, Murphy E, Bradford PA. Keeney D, et al. J Antimicrob Chemother. 2008 Jan;61(1):46-53. doi: 10.1093/jac/dkm397. Epub 2007 Oct 29. J Antimicrob Chemother. 2008. PMID: 17967850
Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae.
Rasmussen BA, Bush K, Keeney D, Yang Y, Hare R, O'Gara C, Medeiros AA. Rasmussen BA, et al. Among authors: keeney d. Antimicrob Agents Chemother. 1996 Sep;40(9):2080-6. doi: 10.1128/AAC.40.9.2080. Antimicrob Agents Chemother. 1996. PMID: 8878585 Free PMC article.
Cloning and expression of a cloxacillin-hydrolyzing enzyme and a cephalosporinase from Aeromonas sobria AER 14M in Escherichia coli: requirement for an E. coli chromosomal mutation for efficient expression of the class D enzyme.
Rasmussen BA, Keeney D, Yang Y, Bush K. Rasmussen BA, et al. Among authors: keeney d. Antimicrob Agents Chemother. 1994 Sep;38(9):2078-85. doi: 10.1128/aac.38.9.2078. Antimicrob Agents Chemother. 1994. PMID: 7811022 Free PMC article.
AsbB1 was a class D enzyme most closely related to the oxacillin-hydrolyzing enzyme OXA-1, with 34% amino acid sequence identity. ...
AsbB1 was a class D enzyme most closely related to the oxacillin-hydrolyzing enzyme OXA-1, with 34% amino acid sequence identity. ...
Increased retention of functional fusions to toxic genes in new two-hybrid libraries of the E. coli strain MG1655 and B. subtilis strain 168 genomes, prepared without passaging through E. coli.
Haney SA, Keeney D, Chen L, Moghazeh S, Projan S, Rasmussen B. Haney SA, et al. Among authors: keeney d. BMC Genomics. 2003 Sep 10;4(1):36. doi: 10.1186/1471-2164-4-36. BMC Genomics. 2003. PMID: 12964949 Free PMC article.
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