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PD-1 and its ligands in tolerance and immunity.
Keir ME, Butte MJ, Freeman GJ, Sharpe AH. Keir ME, et al. Annu Rev Immunol. 2008;26:677-704. doi: 10.1146/annurev.immunol.26.021607.090331. Annu Rev Immunol. 2008. PMID: 18173375 Review.
Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditis.
Mfarrej B, Keir M, Dada S, Trikudanathan S, Sayegh MH, Sharpe AH, Guleria I. Mfarrej B, et al. Among authors: keir m. Clin Immunol. 2011 Jul;140(1):47-53. doi: 10.1016/j.clim.2011.03.011. Epub 2011 Mar 24. Clin Immunol. 2011. PMID: 21498129 Free PMC article.
The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo.
Paterson AM, Brown KE, Keir ME, Vanguri VK, Riella LV, Chandraker A, Sayegh MH, Blazar BR, Freeman GJ, Sharpe AH. Paterson AM, et al. Among authors: keir me. J Immunol. 2011 Aug 1;187(3):1097-105. doi: 10.4049/jimmunol.1003496. Epub 2011 Jun 22. J Immunol. 2011. PMID: 21697456 Free PMC article.
Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles.
Menke J, Lucas JA, Zeller GC, Keir ME, Huang XR, Tsuboi N, Mayadas TN, Lan HY, Sharpe AH, Kelley VR. Menke J, et al. Among authors: keir me. J Immunol. 2007 Dec 1;179(11):7466-77. doi: 10.4049/jimmunol.179.11.7466. J Immunol. 2007. PMID: 18025191
Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart.
Grabie N, Gotsman I, DaCosta R, Pang H, Stavrakis G, Butte MJ, Keir ME, Freeman GJ, Sharpe AH, Lichtman AH. Grabie N, et al. Among authors: keir me. Circulation. 2007 Oct 30;116(18):2062-71. doi: 10.1161/CIRCULATIONAHA.107.709360. Epub 2007 Oct 15. Circulation. 2007. PMID: 17938288
PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues.
Keir ME, Freeman GJ, Sharpe AH. Keir ME, et al. J Immunol. 2007 Oct 15;179(8):5064-70. doi: 10.4049/jimmunol.179.8.5064. J Immunol. 2007. PMID: 17911591
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Butte MJ, et al. Among authors: keir me. Immunity. 2007 Jul;27(1):111-22. doi: 10.1016/j.immuni.2007.05.016. Epub 2007 Jul 12. Immunity. 2007. PMID: 17629517 Free PMC article.
PD-1 and its ligands in T-cell immunity.
Keir ME, Francisco LM, Sharpe AH. Keir ME, et al. Curr Opin Immunol. 2007 Jun;19(3):309-14. doi: 10.1016/j.coi.2007.04.012. Epub 2007 Apr 12. Curr Opin Immunol. 2007. PMID: 17433872 Review.
Tissue expression of PD-L1 mediates peripheral T cell tolerance.
Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH. Keir ME, et al. J Exp Med. 2006 Apr 17;203(4):883-95. doi: 10.1084/jem.20051776. Epub 2006 Apr 10. J Exp Med. 2006. PMID: 16606670 Free PMC article.
The B7/CD28 costimulatory family in autoimmunity.
Keir ME, Sharpe AH. Keir ME, et al. Immunol Rev. 2005 Apr;204:128-43. doi: 10.1111/j.0105-2896.2005.00242.x. Immunol Rev. 2005. PMID: 15790355 Review.
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