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Cardiac Safety Research Consortium: can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies? Scientific update and a research proposal for a path forward.
Darpo B, Garnett C, Benson CT, Keirns J, Leishman D, Malik M, Mehrotra N, Prasad K, Riley S, Rodriguez I, Sager P, Sarapa N, Wallis R. Darpo B, et al. Among authors: keirns j. Am Heart J. 2014 Sep;168(3):262-72. doi: 10.1016/j.ahj.2014.06.003. Epub 2014 Jun 6. Am Heart J. 2014. PMID: 25173536
Reproducibility of QTc interval changes after meal intake.
Hnatkova K, Kowalski D, Keirns JJ, van Gelderen EM, Malik M. Hnatkova K, et al. Among authors: keirns jj. J Electrocardiol. 2015 Mar-Apr;48(2):194-202. doi: 10.1016/j.jelectrocard.2015.01.006. Epub 2015 Jan 8. J Electrocardiol. 2015. PMID: 25601409
QTc changes after meal intake: sex differences and correlates.
Hnatkova K, Kowalski D, Keirns JJ, van Gelderen EM, Malik M. Hnatkova K, et al. Among authors: keirns jj. J Electrocardiol. 2014 Nov-Dec;47(6):856-62. doi: 10.1016/j.jelectrocard.2014.07.026. Epub 2014 Aug 2. J Electrocardiol. 2014. PMID: 25173631
QT/RR curvatures in healthy subjects: sex differences and covariates.
Malik M, Hnatkova K, Kowalski D, Keirns JJ, van Gelderen EM. Malik M, et al. Among authors: keirns jj. Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1798-806. doi: 10.1152/ajpheart.00577.2013. Epub 2013 Oct 25. Am J Physiol Heart Circ Physiol. 2013. PMID: 24163079 Free PMC article.
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