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Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells.
PLoS One. 2009 Dec 14;4(12):e8248. doi: 10.1371/journal.pone.0008248.
PLoS One. 2009.
PMID: 20011520
Free PMC article.
Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium.
Lange AW, Keiser AR, Wells JM, Zorn AM, Whitsett JA.
Lange AW, et al. Among authors: keiser ar.
PLoS One. 2009 May 27;4(5):e5711. doi: 10.1371/journal.pone.0005711.
PLoS One. 2009.
PMID: 19479035
Free PMC article.
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Sox2 activates cell proliferation and differentiation in the respiratory epithelium.
Tompkins DH, Besnard V, Lange AW, Keiser AR, Wert SE, Bruno MD, Whitsett JA.
Tompkins DH, et al. Among authors: keiser ar.
Am J Respir Cell Mol Biol. 2011 Jul;45(1):101-10. doi: 10.1165/rcmb.2010-0149OC. Epub 2010 Sep 20.
Am J Respir Cell Mol Biol. 2011.
PMID: 20855650
Free PMC article.
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Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung.
Maeda Y, Tsuchiya T, Hao H, Tompkins DH, Xu Y, Mucenski ML, Du L, Keiser AR, Fukazawa T, Naomoto Y, Nagayasu T, Whitsett JA.
Maeda Y, et al. Among authors: keiser ar.
J Clin Invest. 2012 Dec;122(12):4388-400. doi: 10.1172/JCI64048. Epub 2012 Nov 12.
J Clin Invest. 2012.
PMID: 23143308
Free PMC article.
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Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation.
Maeda Y, Chen G, Xu Y, Haitchi HM, Du L, Keiser AR, Howarth PH, Davies DE, Holgate ST, Whitsett JA.
Maeda Y, et al. Among authors: keiser ar.
Am J Respir Crit Care Med. 2011 Aug 15;184(4):421-9. doi: 10.1164/rccm.201101-0106OC.
Am J Respir Crit Care Med. 2011.
PMID: 21562130
Free PMC article.
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