Keldenich J - Search Results

1

Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects.

Flamme I, Oehme F, Ellinghaus P, Jeske M, Keldenich J, Thuss U. Flamme I, et al. Among authors: keldenich j. PLoS One. 2014 Nov 13;9(11):e111838. doi: 10.1371/journal.pone.0111838. eCollection 2014. PLoS One. 2014. PMID: 25392999 Free PMC article.

2

Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia.

Beck H, Jeske M, Thede K, Stoll F, Flamme I, Akbaba M, Ergüden JK, Karig G, Keldenich J, Oehme F, Militzer HC, Hartung IV, Thuss U. Beck H, et al. Among authors: keldenich j. ChemMedChem. 2018 May 23;13(10):988-1003. doi: 10.1002/cmdc.201700783. Epub 2018 Apr 14. ChemMedChem. 2018. PMID: 29485740 Free PMC article.

3

Effects of different pulmonary vasodilators on arterial saturation in a model of pulmonary hypertension.

Becker EM, Stasch JP, Bechem M, Keldenich J, Klipp A, Schaefer K, Ulbrich HF, Truebel H. Becker EM, et al. Among authors: keldenich j. PLoS One. 2013 Aug 28;8(8):e73502. doi: 10.1371/journal.pone.0073502. eCollection 2013. PLoS One. 2013. PMID: 24015306 Free PMC article.

4

Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase.

Hatzelmann A, Fruchtmann R, Mohrs KH, Raddatz S, Matzke M, Pleiss U, Keldenich J, Müller-Peddinghaus R. Hatzelmann A, et al. Among authors: keldenich j. Agents Actions. 1994 Nov;43(1-2):64-8. doi: 10.1007/BF02005767. Agents Actions. 1994. PMID: 7741044 Review.

5

In silico ADMET traffic lights as a tool for the prioritization of HTS hits.

Lobell M, Hendrix M, Hinzen B, Keldenich J, Meier H, Schmeck C, Schohe-Loop R, Wunberg T, Hillisch A. Lobell M, et al. Among authors: keldenich j. ChemMedChem. 2006 Nov;1(11):1229-36. doi: 10.1002/cmdc.200600168. ChemMedChem. 2006. PMID: 16991174

6

Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides.

Urbahns K, Härter M, Albers M, Schmidt D, Stelte-Ludwig B, Brüggemeier U, Vaupel A, Keldenich J, Lustig K, Tsujishita H, Gerdes C. Urbahns K, et al. Among authors: keldenich j. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6151-4. doi: 10.1016/j.bmcl.2007.09.039. Epub 2007 Sep 14. Bioorg Med Chem Lett. 2007. PMID: 17910915

7

Volume to dissolve applied dose (VDAD) and apparent dissolution rate (ADR): tools to predict in vivo bioavailability from orally applied drug suspensions.

Muenster U, Pelzetter C, Backensfeld T, Ohm A, Kuhlmann T, Mueller H, Lustig K, Keldenich J, Greschat S, Göller AH, Gnoth MJ. Muenster U, et al. Among authors: keldenich j. Eur J Pharm Biopharm. 2011 Aug;78(3):522-30. doi: 10.1016/j.ejpb.2011.01.023. Epub 2011 Feb 16. Eur J Pharm Biopharm. 2011. PMID: 21315152

8

CypScore: Quantitative prediction of reactivity toward cytochromes P450 based on semiempirical molecular orbital theory.

Hennemann M, Friedl A, Lobell M, Keldenich J, Hillisch A, Clark T, Göller AH. Hennemann M, et al. Among authors: keldenich j. ChemMedChem. 2009 Apr;4(4):657-69. doi: 10.1002/cmdc.200800384. ChemMedChem. 2009. PMID: 19243088

9

Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X1005. Implications for biological regulation of 5-lipoxygenase.

Hatzelmann A, Fruchtmann R, Mohrs KH, Raddatz S, Matzke M, Pleiss U, Keldenich J, Müller-Peddinghaus R. Hatzelmann A, et al. Among authors: keldenich j. Adv Prostaglandin Thromboxane Leukot Res. 1994;22:23-31. Adv Prostaglandin Thromboxane Leukot Res. 1994. PMID: 7771337 Review. No abstract available.

10

In silico prediction of buffer solubility based on quantum-mechanical and HQSAR- and topology-based descriptors.

Göller AH, Hennemann M, Keldenich J, Clark T. Göller AH, et al. Among authors: keldenich j. J Chem Inf Model. 2006 Mar-Apr;46(2):648-58. doi: 10.1021/ci0503210. J Chem Inf Model. 2006. PMID: 16562995

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